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Virus-like Particles of a Fraction of Statolon, a Mould Product


STATOLON, a fermentation product of a mould, Penicillium stoloniferum, is capable of stimulating the production of interferon in animals and in tissue culture1,2. It was previously reported that the activity of the partially purified statolon is associated with a sedimentable anionic polysaccharide3. Attempts to refine further the statolon preparations were hampered by its low solubility and its tendency to aggregate with itself and other materials causing inactivation. Elucidation of the physical characteristics of statolon has recently been extended by means of centrifugation on sucrose density gradients and electron microscopic studies. It was found that it was possible to avoid aggregation if sodium chloride was added to the gradients and if the pH was kept near 9.

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ELLIS, L., KLEINSCHMIDT, W. Virus-like Particles of a Fraction of Statolon, a Mould Product. Nature 215, 649–650 (1967).

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