Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Virus-like Particles of a Fraction of Statolon, a Mould Product

Abstract

STATOLON, a fermentation product of a mould, Penicillium stoloniferum, is capable of stimulating the production of interferon in animals and in tissue culture1,2. It was previously reported that the activity of the partially purified statolon is associated with a sedimentable anionic polysaccharide3. Attempts to refine further the statolon preparations were hampered by its low solubility and its tendency to aggregate with itself and other materials causing inactivation. Elucidation of the physical characteristics of statolon has recently been extended by means of centrifugation on sucrose density gradients and electron microscopic studies. It was found that it was possible to avoid aggregation if sodium chloride was added to the gradients and if the pH was kept near 9.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Kleinschmidt, W. J., Cline, J. C., and Murphy, E. B., Proc. US Nat. Acad. Sci., 52, 741 (1964).

    Article  ADS  CAS  Google Scholar 

  2. Kleinschmidt, W. J., and Murphy, E. B., Virology, 27, 484 (1965).

    Article  CAS  Google Scholar 

  3. Kleinschmidt, W. J., and Probst, G. W., Antibiot. and Chemother., 12, 298 (1962).

    CAS  Google Scholar 

  4. Anderson, N. G., Nat. Cancer Inst. Monograph 21 (US Government Printing Office, Washington, D. C., 1966).

  5. Lindberg, G. D., Phytopathology, 49, 29 (1959).

    Google Scholar 

  6. Jinks, J. L., J. Gen. Microbiol., 21, 397 (1959).

    Article  CAS  Google Scholar 

  7. Grogan, R. G., and Campbell, R. N., Ann. Rev. Phytopathol., 4, 29 (1966).

    Article  Google Scholar 

  8. Lindegren, C. C., and Bang, Y. N., Antonie van Leeuwenhoek, 27, 1 (1961).

    Google Scholar 

  9. Lindegren, C. C., Bang, Y. N., and Hirano, T., Trans. NY Acad. Sci., 24, 540 (1962).

    Article  CAS  Google Scholar 

  10. Hollings, M., Nature, 196, 962 (1962).

    Article  ADS  Google Scholar 

  11. Hollings, M., Gandy, D. G., and Last, F. T., Endeavour, 22, 112 (1963).

    Article  CAS  Google Scholar 

  12. Tsuda, S., and Tatum, E. L., J. Biophys. Biochem. Cytol., 11, 171 (1961).

    Article  CAS  Google Scholar 

  13. Luria, S. E., General Virology (John Wiley and Sons, Inc., London, 1953).

    Google Scholar 

  14. Smith, K. M., and Williams, R. C., Endeavour, 17, 12 (1958).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

ELLIS, L., KLEINSCHMIDT, W. Virus-like Particles of a Fraction of Statolon, a Mould Product. Nature 215, 649–650 (1967). https://doi.org/10.1038/215649a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/215649a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing