Abstract
A calculation of the extent of the differences between homologous proteins shows that the amino-acid “mutations” are not as random as might have been thought. In fact, natural selection seems to act to favour those amino-acid substitutions that tend to maintain the original conformation of the protein.
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EPSTEIN, C. Non-randomness of Ammo-acid Changes in the Evolution of Homologous Proteins. Nature 215, 355–359 (1967). https://doi.org/10.1038/215355a0
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DOI: https://doi.org/10.1038/215355a0
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