Abstract
THE histochemical detection of early changes in the characteristics, distribution and enzyme contents of lysosomes, as well as their cycles of appearance and disappearance, affords a sensitive index of toxic effects on the cell. Hypoxia is known to labilize lysosomes1 and might be expected to render them more susceptible to adverse influences. Selective uptake of neutral red by lysosomes2,3 and the stabilization brought about by chloroquine4 constitute further experimental manipulations to which lysosomes can be subjected. We have made detailed observations of lysosomal behaviour in these conditions as a preliminary to the study of lysosomal changes in the damaged liver of the rat.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Weissmann, G., New Engl. J. Med., 273, 1143 (1965).
Allison, A. C., and Young, M. R., Life Sci., 3, 1407 (1964).
Hafiek, B., and Kovács, J., Annals Univ. Scient. Bdpest. Rolando Eötvös, 1, Sectio Biologica., 7, 105 (1964).
Gomori, G., Microscopic Histochemistry Principles and Practice (University of Chicago Press, 1952).
Novikoff, A. B., Ciba Foundation Symposium on Lysosomes (edit. by de Reuck, A. V. S., and Cameron, M. P.), 67 (London, 1963).
Barka, T., and Anderson, P. J., J. Histochem. Cytochem., 10, 741 (1962).
Hayashi, M., Nakajima, Y., and Fishman, W. H., J. Histochem. Cytochem., 12, 293 (1964).
Fishman, W. H., and Goldman, S. S., J. Histochem. Cytochem., 13, 441 (1965).
de Duve, C., and Wattiaux, R., Ann. Rev. Physiol., 28, 435 (1966).
Allison, A. C., and Mallucci, L., Lancet, ii, 1371 (1964).
Hirschhorn, K., and Hirschhorn, R., Lancet, i, 1046 (1965).
Allison, A. C., and Paton, G. R., Nature, 207, 1170 (1965).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
ABRAHAM, R., GOLBERG, L. & GRASSO, P. Hepatic Response to Lysosomal Effects of Hypoxia, Neutral Red and Chloroquine. Nature 215, 194–196 (1967). https://doi.org/10.1038/215194a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/215194a0
This article is cited by
-
Effect of subextremal and extremal factors on liver lysosomes
Bulletin of Experimental Biology and Medicine (1977)
-
Uptake of tritium labelled chloroquine into organized cultures of rat spinal ganglia
Acta Neuropathologica (1975)
-
Zur Entstehung cytoplasmatischer Vakuolen von Leukocyten im in-vitro-Versuch
Klinische Wochenschrift (1974)
-
Possible ways of influencing the mechanisms of sclerosis in experimental silicosis
Bulletin of Experimental Biology and Medicine (1973)
-
Die Mitosehäufigkeit in der normalen Epidermis der Maus nach einmaliger DMSO-Einwirkung
Experientia (1973)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
