Steroid Hormones in Sickle-cell Disease

Abstract

Progesterone, testosterone and nor-androstenolone can inhibit the development of sickling in sickle cell disease, which they seem to do by stabilizing the membrane of the erythrocyte. This could be medically useful.

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References

  1. 1

    Pauling, L., Itano, H. A., Singer, S. J., and Wells, I. C., Science, 110, 543 (1949).

  2. 2

    Ingram, V. M., Nature, 180, 326 (1957).

  3. 3

    Hunt, J. A., and Ingram, V. M., Nature, 184, 640 (1959).

  4. 4

    Perutz, M. F., and Mitchison, M. J., Nature, 166, 677 (1950).

  5. 5

    Harris, J. W., Proc. Soc. Exp. Biol. and Med., 75, 197 (1950).

  6. 6

    Murayama, M., Science, 153, 145 (1966).

  7. 7

    Hathorn, M., and Lewis, R. A., Brit. J. Haematol., 12, 195 (1966).

  8. 8

    Lewis, R. A., and Gyang, F. N., Arch. Intern. Pharmacodyn., 153, 158 (1965).

  9. 9

    Kosower, E. M., Kosower, N. S., and La Course, P. C., Proc. US Nat. Acad. Sci., 57, 39 (1967).

  10. 10

    Daland, G. A., and Castle, W. B., J. Lab. Clin. Med., 33, 1082 (1948).

  11. 11

    Dacie, J. V., and Lewis, S. M., Practical Haematology, third ed. (J. and A. Churchill, Ltd., London, 1963).

  12. 12

    Bromberg, P. A., and Bessis, M. C., Science, 155, 704 (1967).

  13. 13

    De Venuto, F., Proc. Soc. Exp. Biol. and Med., 124, 478 (1967).

  14. 14

    Purugaanan, H. B., and McElfresh, A. E., Lancet, 70 (1964).

  15. 15

    Beutler, E., and Mikus, B. J., J. Clin. Invest., 40, 1856 (1961).

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