LOUCKS first showed that electrical stimulation of the cerebral cortical surface could serve as a conditioned stimulus in a behavioural situation1. A number of workers have been concerned with this issue since the original findings2–4. It is now well established that stimulation of subcortical as well as cortical sites can serve as conditioned stimuli. Of particular interest is the fact that when a stimulus has been established, very limited primary generalization to brain sites other than the conditioned site occurs5. For example, if a stimulus applied to the head of the caudate nucleus is used as the conditioned stimulus, generalization is found only in homotopic contralateral caudate sites and in nearby points in the same structure4.
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ROMERO-SIERRA, C., BUCHWALD, N., WAKEFIELD, C. et al. Two Point Discrimination of Subcortical Electrical Stimulation. Nature 214, 837–838 (1967). https://doi.org/10.1038/214837a0
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