Does the Agent of Scrapie Replicate without Nucleic Acid ?

Abstract

Scrapie is a slowly developing disease of the nervous system. Experiments on the effects of ultra-violet irradiation of suspensions of infected mouse brain extracts confirm that the agent responsible for it does not depend on a nucleic acid for its ability to replicate. No evidence is obtained, however, to indicate whether the agent is associated with a protein.

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ALPER, T., CRAMP, W., HAIG, D. et al. Does the Agent of Scrapie Replicate without Nucleic Acid ?. Nature 214, 764–766 (1967). https://doi.org/10.1038/214764a0

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