Abstract
Magee and Nakamura have reported1 that a pancreozymin and cholecystokinin (PZ/CCK) preparation increased gastric secretion in dogs with a simple gastric fistula. The authors, I am sure, have overlooked previous reports of this finding2,3. Using a commmercial and highly purified preparation of PZ/CCK, ‘Cecekin’ (Vitrum), it was found that doses ranging from 18.75 to 600 U/h increased gastric acid output in dogs with a simple gastric fistula2. These investigations were confirmed in later experiments in which bethanechol (‘Urecholine’) was combined with ‘Cecekin’. In those experiments3, bethanechol plus ‘Cecekin’ produced a greater acid response than bethanechol alone.
Similar content being viewed by others
Article PDF
References
Magee, D. F., and Nakamura, M., Nature, 212, 1487 (1966).
Preshaw, R. M., and Grossman, M. I., Gastroenterology, 48, 36 (1965).
Preshaw, R. M., Adashek, K., Cooke, A. R., and Grossman, M. I., Proc. Soc. Exp. Biol. and Med., 119, 1040 (1965).
Cooke, A. R., and Grossman, M. I., Gastroenterology, 51, 506 (1966).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
COOKE, A. Effect of Pancreozymin Preparations on Gastric Secretion. Nature 214, 729 (1967). https://doi.org/10.1038/214729a0
Issue Date:
DOI: https://doi.org/10.1038/214729a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.