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Lymphocytes in Congenital Absence of the Thymus

Abstract

Lymphocytes of presumably extrathymic origin were obtained from an immunologically deficient child in whom there was complete failure of development of the thymus. They were poorly responsive to phytohaemagglutinin and to antigens, and responsiveness was not induced by incubation with thymic or transfer factors.

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LISCHNER, H., PUNNETT, H. & DiGEORGE, A. Lymphocytes in Congenital Absence of the Thymus. Nature 214, 580–582 (1967). https://doi.org/10.1038/214580a0

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