Abstract
‘FREONS’ are fluorocarbons, with 1–4 carbon atoms, fluorine and sometimes chlorine, bromine or hydrogen, which are widely used as propellants (for example, with pressurized aerosols of foods or pesticides), fire extinguishers, solvents, and refrigerants. ‘Freons’ have low toxicity after acute or chronic inhalation exposures1,2, with the exception of halothane, CF3-CHBrCl, which has produced occasional hepatotoxicity, possibly as a result of fluoroalkene contaminant3.
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EPSTEIN, S., JOSHI, S., ANDREA, J. et al. Synergistic Toxicity and Carcinogenicity of ‘Freons’ and Piperonyl Butoxide. Nature 214, 526–528 (1967). https://doi.org/10.1038/214526a0
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DOI: https://doi.org/10.1038/214526a0
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