Letter | Published:

Haemolytic Activity of Asbestos and other Mineral Dusts

Naturevolume 214pages522523 (1967) | Download Citation

Subjects

Abstract

SILICA in the particulate form has been shown to have a lytic action on intracellular structures1–3 and on erythrocytes3,4. The present investigation has shown that chrysotile asbestos is as potent a haemolytic agent as silica powder. Other forms of asbestos lysed erythrocytes only after prolonged incubation with them, and a wide range of mineral dusts was inactive. The haemolytic action of chrysotile was completely prevented by disodium versenate and simple phosphates but only partially by polyvinylpyridine-N-oxide and aluminium, both of which protect cells against lysis by silica1.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Harington, J. S., and Allison, A. C., Med. Lavoro, 56, 471 (1965).

  2. 2

    Allison, A. C., Harington, J. S., and Birbeck, M., J. Exp. Med., 124, 141 (1966).

  3. 3

    Nash, T., Allison, A. C., and Harington, J. S., Nature, 210, 259 (1966).

  4. 4

    Stalder, K., and Stöber, W., Nature, 207, 874 (1965).

  5. 5

    Schulman, J. H., and Rideal, E. K., Proc. Roy. Soc., B122, 46 (1937).

  6. 6

    Clark, S. G., and Holt, P. F., Trans. Farad. Soc., 53, 1509 (1957).

  7. 7

    Clark, S. G., Holt, P. F., and Went, C. W., Trans. Farad. Soc., 53, 1500 (1957).

  8. 8

    Fielding, J., and Smith, G. M., J. Clin. Path., 16, 12 (1963).

  9. 9

    Charache, P., Macleod, C. M., and White, P., J. Gen. Physiol., 45, 1117 (1962).

  10. 10

    Naumann, A. W., and Dresher, W. H., J. Phys. Chem., 70, 288 (1966).

Download references

Author information

Affiliations

  1. South African Institute for Medical Research, P.O. Box 1038, Johannesburg, Republic of South Africa

    • GWEN MACNAB
    •  & J. S. HARINGTON

Authors

  1. Search for GWEN MACNAB in:

  2. Search for J. S. HARINGTON in:

About this article

Publication history

Issue Date

DOI

https://doi.org/10.1038/214522a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.