Letter | Published:

Activity of a Macrophage Factor in Collagen Formation by Silica

Naturevolume 214pages521522 (1967) | Download Citation

Subjects

Abstract

THE first response of cells to the deposition of free silica particles is phagocytosis. The way in which this is followed by fibrosis is not understood, although macrophages are thought to liberate a fibrogenic agent when they die1–4. There is a correlation between the toxicity of various forms of silica and of other particulate materials to macrophages in culture and the capacity of these particles to stimulate fibrosis in vivo2,5–7, but this relationship does not seem to have been demonstrated directly in tissue culture.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Fallon, J. T., Canad. Med. Assoc. J., 36, 223 (1937).

  2. 2

    Marks, J., and Nagelschmidt, G., Amer. Med. Assoc. Arch. Indust. Health, 20, 383 (1959).

  3. 3

    Curran, R. C., and Ager, J. A. M., J. Path. Bact., 83, 1 (1962).

  4. 4

    Vigliani, E. C., and Pernis, B., Adv. Tuberculosis Res., 12, 230 (1963).

  5. 5

    Marks, J., Mason, M. A., and Nagelschmidt, G., Brit. J. Indust. Med., 13, 187 (1956).

  6. 6

    Vigliani, E. C., Pernis, B., and Monaco, L., in Inhaled Particles and Vapours (edit. by Davies, C. N.), 348 (Pergamon Press, London, 1961).

  7. 7

    Schlipköter, H.-W., and Beck, E. G., Med. Lavoro, 56, 485 (1965).

  8. 8

    Trowell, O. A., Exp. Cell. Res., 16, 118 (1959).

  9. 9

    Ceriotti, G., J. Biol. Chem., 198, 297 (1952).

  10. 10

    Woessner, J. F., Arch. Biochem. Biophys., 93, 440 (1961).

  11. 11

    Schlipköter, H.-W., and Brockhaus, A., Dtsch. Med. Wschr., 85, 920 (1960).

  12. 12

    Schlipköter, H.-W., and Brockhaus, A., Klin. Wschr., 39, 1182 (1961).

  13. 13

    Beck, E. G., Bruch, J., and Brockhaus, A., Z. Zellforsch., 59, 568 (1963).

  14. 14

    Harington, J. S., S. African Med. J., 37, 451 (1963).

  15. 15

    Webster, I., and Marasas, L., S. African Council for Sci. and Indust. Res., Ninth Ann. Rep., 22 (1965).

Download references

Author information

Affiliations

  1. Department of Pathology, University of Newcastle upon Tyne, Royal Victoria Infirmary, Newcastle upon Tyne

    • A. G. HEPPLESTON
    •  & J. A. STYLES

Authors

  1. Search for A. G. HEPPLESTON in:

  2. Search for J. A. STYLES in:

About this article

Publication history

Issue Date

DOI

https://doi.org/10.1038/214521a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.