Abstract
IN continuing our examination of microbiological degradation of bile acid1–3, we found that when cholic acid (I) was incubated with the same method as described in a previous paper4, a new metabolite of cholic acid by Corynebacterium (Arthrobacter) simplex, 4α-(2-carboxyethyl)-5-oxo-7αβ,γdimethyl-3aα-hexahydroindane-1β-butyric hexahydroindane-1β-butyric acid (IX), was accumulated in the incubation mixture in parallel with a disappearance of a large number of the cholic acid metabolites, 7α,12α-dihydroxy-3-oxocholanic (II), 7α,12α -dihydroxy-3-oxo-Δ4-cholenic (III), 12α-hydroxy-3-oxo-Δ4,6-choladienic (IV), 12α-hydroxy-3-oxo-Δ4-cholenic (V) and 12α-hydroxy-3-oxo-Δ1,4-choladienic (VI) acids reported previously4, from the incubation mixture.
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References
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HAYAKAWA, S., KANEMATSU, Y. & FUJIWARA, T. New Dehydroxylation Reaction observed in the Microbiological Degradation Pathway of Cholic Acid. Nature 214, 520–521 (1967). https://doi.org/10.1038/214520b0
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DOI: https://doi.org/10.1038/214520b0
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