Letter | Published:

Colony Production in vitro by Normal Polycythaemic and Anaemic Bone Marrow

Naturevolume 214page511 (1967) | Download Citation

Subjects

Abstract

THE growth of colonies from mouse bone marrow cells in solid agar medium in vitro has been described recently1. The colony growth required stimulation by feeder layer cells, the most effective of which were neonatal mouse kidney cells. Although the colonies appear to arise by the proliferation of single cells, the colony cell population is a mixture of myeloid cells and mononuclear cells and the identity of the cells responsible for the initiation of colony formation has not been established. In order to gain more information on the in vitro colony forming cells the following studies have been made comparing the numbers of colony forming cells in normal, polycythaemic and anaemic mouse bone marrows.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Bradley, T. R., and Metcalf, D., Austral. J. Exp. Biol. Med. Sci., 14, 287 (1966).

  2. 2

    Alpen, E. L., Cranmore, D., and Johnston, M. E., in Erythropoiesis (edit. by Jacobson, L. O., and Doyle, M.), 184 (Grune and Stratton, New York, 1962).

Download references

Author information

Affiliations

  1. Department of Physiology, University of Melbourne Parkville, Victoria, Australia

    • T. R. BRADLEY
  2. Cancer Research Unit, Walter and Eliza Hall Institute, Melbourne, Australia

    • W. ROBINSON
    •  & D. METCALF

Authors

  1. Search for T. R. BRADLEY in:

  2. Search for W. ROBINSON in:

  3. Search for D. METCALF in:

About this article

Publication history

Issue Date

DOI

https://doi.org/10.1038/214511a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.