Letter | Published:

A New Marker for Chromosome Studies in the Mouse

Naturevolume 214pages504505 (1967) | Download Citation



THE mouse is one of the best mammals for genetic and cytogenetic investigations. Unfortunately, its value for cytogenetic research is restricted because all forty chromosomes are acrocentric. Their sizes range in the ratio of 5 : 2 (longest to shortest) with relatively little difference other than length to help in identification. At the first metaphase stage of meiosis, twenty bivalents are normally formed and this pairing is commonly used to correlate abnormal configurations with specific chromosome changes. It is obvious, however, that cellular markers (cells with a visible different karyotype from the normal) would be useful for transplantation experiments and work on carcinogenesis or radiation chimeras. Some translocations induced in mice by X-irradiation have been used as such cellular markers1,2.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Ford, C. E., Hamerton, J. L., Barnes, D. W. H., and Loutit, J. F., Nature, 177, 452 (1956).

  2. 2

    Welshons, W. J., Mammalian Cytogenesis and Related Problems in Radiobiology (Pergamon Press, London, 1964).

  3. 3

    Léonard, A., and Deknudt, Gh., Canad. J. Gen. Cytol., 8, 520 (1966).

  4. 4

    Stich, H. F., and Hsu, T. C., Exp. Cell Res., 20, 248 (1960).

  5. 5

    Ford, C. E., Hamerton, J. L., and Sharman, G. B., Nature, 180, 392 (1957).

Download references

Author information


  1. Laboratoire de Génétique, Département de Radiobiologie, Centre d'Etude de l'Energie Nucléaire, Mol, Belgium

    • A. LÉONARD
    •  & GH. DEKNUDT


  1. Search for A. LÉONARD in:

  2. Search for GH. DEKNUDT in:

About this article

Publication history

Issue Date



Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.