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A New Marker for Chromosome Studies in the Mouse

Naturevolume 214pages504505 (1967) | Download Citation

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Abstract

THE mouse is one of the best mammals for genetic and cytogenetic investigations. Unfortunately, its value for cytogenetic research is restricted because all forty chromosomes are acrocentric. Their sizes range in the ratio of 5 : 2 (longest to shortest) with relatively little difference other than length to help in identification. At the first metaphase stage of meiosis, twenty bivalents are normally formed and this pairing is commonly used to correlate abnormal configurations with specific chromosome changes. It is obvious, however, that cellular markers (cells with a visible different karyotype from the normal) would be useful for transplantation experiments and work on carcinogenesis or radiation chimeras. Some translocations induced in mice by X-irradiation have been used as such cellular markers1,2.

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References

  1. 1

    Ford, C. E., Hamerton, J. L., Barnes, D. W. H., and Loutit, J. F., Nature, 177, 452 (1956).

  2. 2

    Welshons, W. J., Mammalian Cytogenesis and Related Problems in Radiobiology (Pergamon Press, London, 1964).

  3. 3

    Léonard, A., and Deknudt, Gh., Canad. J. Gen. Cytol., 8, 520 (1966).

  4. 4

    Stich, H. F., and Hsu, T. C., Exp. Cell Res., 20, 248 (1960).

  5. 5

    Ford, C. E., Hamerton, J. L., and Sharman, G. B., Nature, 180, 392 (1957).

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Affiliations

  1. Laboratoire de Génétique, Département de Radiobiologie, Centre d'Etude de l'Energie Nucléaire, Mol, Belgium

    • A. LÉONARD
    •  & GH. DEKNUDT

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https://doi.org/10.1038/214504a0

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