Letter | Published:

Selection against Chromosome Aberrations in Human Lymphocytes

Naturevolume 214pages502503 (1967) | Download Citation

Subjects

Abstract

THE frequency of chromosome aberrations in the lymphocytes of people who have been exposed to ionizing radiation decreases for many years, beginning some 2–3 weeks after irradiation, at a rate that depends on the type of aberration1,2. Differences in the rates at which the various types of aberration are eliminated are probably caused by differences in the selection against these aberrations at cell division. No data, however, have been reported on the probability that a given aberration in a human lymphocyte will survive cell division. In this communication we present such data obtained in vitro, together with some new data on the elimination of aberrations in vivo. The two sets of data suggest that the lymphocyte, when stimulated to divide in vivo, will undergo several successive divisions.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Buckton, K. E., Jacobs, P. A., Court Brown, W. M., and Dall, R., Lancet. ii, 676 (1962).

  2. 2

    Norman, A., Sasaki, M. S., Ottoman, R. E., and Fingerhut, A. G., Blood, 27, 706 (1966).

  3. 3

    Sasaki, M. S., and Norman, A., Nature, 210, 913 (1966).

  4. 4

    Grundmann, E., Beitr. Path. Anat. allgem. Pathol., 119, 217 (1958).

  5. 5

    Sainte-Marie, G., and Leblond, C. P., Proc. Soc. Exp. Biol. and Med., 99, 263 (1958).

Download references

Author information

Affiliations

  1. Department of Radiology, UCLA School of Medicine, Los Angeles, California

    • MASAO S. SASAKI
    •  & AMOS NORMAN

Authors

  1. Search for MASAO S. SASAKI in:

  2. Search for AMOS NORMAN in:

About this article

Publication history

Issue Date

DOI

https://doi.org/10.1038/214502a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.