Letter | Published:

Studies of the Distribution of Haemoglobin E, Thalassaemias and Glucose-6-phosphate Dehydrogenase Deficiency in North-eastern Thailand

Naturevolume 214pages501502 (1967) | Download Citation

Subjects

Abstract

DURING our survey in 1963, examinations were made of 1,030 subjects in the provinces of Ubol(rajthani), Khonkaen and Udorn(thani) in north-eastern Thailand. The subjects were villagers, soldiers, hospital patients and prisoners. Haemoglobin types were based on cellulose acetate strip electrophoresis in veronal buffer, pH. 8.6, ionic strength 0.025. Thalassaemia trait was designated to those with Hb A who showed decreased red cell osmotic fragility in a one tube screening method1, hypochromic microcytic red cells and serum iron not lower than 50γ per cent; these persons who had Hb A2, as determined by starch block electrophoresis2,3, higher than 3.1 per cent were further classified as β-thalassaemia traits and the others with 3.1 per cent Hb A2 or lower as α-thalassaemia traits. In Ubol glucose-6-phosphate dehydrogenase (G-6-PD) activity was screened with Motulsky's technique4, but in Khonkaen and Udorn a spot test was carried out according to Fairbanks and Beutler5.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Malamos, B., Fessas, P., and Stamatoyannopoulos, G., Brit. J. Haematol., 8, 5 (1962).

  2. 2

    Kunkel, H. G., and Wallenius, G., Science, 122, 288 (1955).

  3. 3

    Gerald, P. S., and Diamond, L. K., Blood, 13, 61 (1958).

  4. 4

    Motulsky, A. G., and Campbell, J. M., Proc. Genet. Conf. Polymorphisms and Geographic Variations in Disease, 258 (edit. by Blumberg, B. S.) (1960).

  5. 5

    Fairbanks, V., and Beutler, E., Blood, 20, 591 (1962).

  6. 6

    Chernoff, A. I., Minnich, V., Na-Nakorn, S., Tuchinda, S., Kashemsant, C., and Chernoff, R. R., J. Lab. Clin. Med., 47, 455 (1956).

  7. 7

    Na-Nakorn, S., and Minnich, V., Blood, 12, 529 (1957).

  8. 8

    Flatz, G., Pik, C., and Sringam, S., Ann. Hum. Genet., 29, 151 (1965).

  9. 9

    Lie-Injo, L. E., and Poey-Oey, H. G., Nature, 204, 88 (1964).

  10. 10

    Bernini, L., Carcassi, U., Latte, B., Motulsky, A. G., Romei, L., and Siniscalco, M., Atti Accad. Naz. Lincei, R. C., 29, 1 (1960).

  11. 11

    Siniscalco, M., Bernini, L., Latte, B., and Motulsky, A. G., Nature, 190, 1179 (1961).

  12. 12

    Na-Nakorn, S., Minnich, V., and Chernoff, A. I., J. Lab. Clin. Med., 47, 490 (1956).

  13. 13

    Sundharagiati, B., and Viseshakul, B. J., Med. Serv. Dept., Bangkok, 8, 388 and 397 (1959).

  14. 14

    Kruatrachue, M., Charoenlap, P., Chongsuppajaisiddhi, T., and Harinasuta, C., Lancet, ii, 1183 (1962).

  15. 15

    Flatz, G., and Sringam, S., Lancet, ii, 1248 (1963).

  16. 16

    Thirayothin, P., and Sitachitt, P., Ann. Prog. Rep. of Seato Med. Res. Lab., Bangkok (1964).

  17. 17

    Cadnaphaphornchai, P., Chayapruks, P., Vichayanrat, A., Sukachevin, R., Kanokvechayant, R., Kitibutara, K., Raksaphao, S., and Wasi, P., Siriraj Hosp. Gazette, Bangkok, 18, 411 (1966).

  18. 18

    Tuchinda, S., Vareenil, C., Bhanchit, P., and Minnich, V., Pediatrics, 24, 43 (1959).

  19. 19

    Pootrakul, S., Wasi, P., and Na-Nakorn, S., Ann. Hum. Genet. (in the press).

  20. 20

    Sangvichien, S., Curr. Anthrop., 7, 234 (1966).

  21. 21

    Kruatrachue, M., Na-Nakorn, S., Charoenlap, P., and Suwanakul, I., Ann. Trop. Med. Parasitol. 55, 468 (1961).

  22. 22

    Flatz, G., Pik, C., and Sundharagiati, B., Lancet, ii, 385 (1964).

  23. 23

    Plato, C. C., Rucknagel, D. L., and Gershowitz, H., Amer. J. Hum. Genet., 16, 267 (1964).

Download references

Author information

Affiliations

  1. Division of Haematology, Department of Medicine, Faculty of Medicine and Siriraj Hospital, Bangkok, Thailand

    • P. WASI
    • , S. NA-NAKORN
    •  & A. SUINGDUMRONG

Authors

  1. Search for P. WASI in:

  2. Search for S. NA-NAKORN in:

  3. Search for A. SUINGDUMRONG in:

About this article

Publication history

Issue Date

DOI

https://doi.org/10.1038/214501a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.