Letter | Published:

Antilipoprotein Nuoro Serum (C.P.) and its Relation to Sera C. de B. and L.L.

Naturevolume 214pages495496 (1967) | Download Citation



SINCE the original observation by Marie1 that sera from poly-transfused subjects can cause precipitate formation with some but not all human sera, several isoprecipitin sera with various specificities have been discovered. The first reagent to be more closely investigated was serum C. de B. found by Allison and Blumberg2. This antiserum was originally denoted anti-Ag (a+) and sera reacting positively with this serum were regarded as being Ag (a +). One of us (J.H.), however, showed that serum C. de B. is a mixture of at least three physically separable antibodies3 and the notation anti-a1 anti-x and anti-z was adopted for these three antibodies3,4. Thus sera which previously had been regarded as Ag (a +) could be any of seven different combinations of the three antigens a1, x and z.

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  1. 1

    Marie, P.-L., C.R. Soc. Biol., 79, 149 (1916).

  2. 2

    Allison, A. C., and Blumberg, B. S., Lancet, i, 634 (1961).

  3. 3

    Hirschfeld, J., Science Tools, 10, 45 (1963).

  4. 4

    Hirschfeld, J., Blumberg, B. S., and Allison, A. C., Nature, 202, 706 (1964).

  5. 5

    Hirschfeld, J., and Blombäck, M., Nature, 201 1337 (1964).

  6. 6

    Hirschfeld, J., and Blumberg, B. S., Nature (in the press).

  7. 7

    Contu, L., Nouv. Rev. Franç. d'Hematol. (in the press).

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  1. State Institute for Blood Group Serology, Statens Rättskemiska Laboratorium, Stockholm, 60

  2. Hopital Civil, Nuoro, Italy

  3. Institute for Cancer Research Fox Chase, Philadelphia, Pennsylvania

    • B. S. BLUMBERG


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