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Pitfalls in Electron Spin Resonance Spectrometry in Biological Tissues

Naturevolume 214pages492493 (1967) | Download Citation



WE have been following with interest the papers concerning electron spin resonance (ESR) signals in biological materials published by various workers in the USSR, the United Kingdom, and the United States1–6. Since the published results in selected normal and tumorous tissues conflict in reporting the presence or absence of an ESR signal at about 2.004 g, we investigated several of the variables in the detection of the signal and its amplitude. We feel it is important for workers in the biological and pathological field to follow standard procedures and to be aware of simple factors which affect the ESR signals but have not as yet appeared in print. With proper technique it may be possible to obtain signals from every type of tissue.

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  1. 1

    Klochko, E. V., Chibrikin, V. M., Kruglyakova, K. Ye., and Emanuel, N. M., Biofizika, 11, 443 (1966).

  2. 2

    Mallard, J. R., and Kent, M., Nature, 210, 588 (1966).

  3. 3

    Kent, M., and Mallard, J. R., Nature, 207, 1195 (1965).

  4. 4

    Commoner, B., Townsend, S., and Pake, G. E., Nature, 174, 689 (1954).

  5. 5

    Commoner, B., and Ternberg, J. L., Proc. U.S. Nat. Acad. Sci., 47, 1374 (1961).

  6. 6

    Vithayathil, A. J., Ternberg, J. L., and Commoner, B., Nature, 207, 1246 (1965).

  7. 7

    Becker, R. O., and Marino, A. A., Nature, 210, 583 (1966).

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  1. Stein Research Center, Department of Radiology, Jefferson Medical Centre, Philadelphia, Pennsylvania

    • C. M. DETTMER
    • , D. H. DRISCOLL
    •  & J. D. WALLACE
  2. Materials Science and Engineering Division, The Franklin Institute Research Laboratories, Philadelphia, Pennsylvania

    • A. NEAVES


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