Letter | Published:

Incorporation of Exogenous (Phage) DNA into Amphibian Oocytes

Naturevolume 214page491 (1967) | Download Citation



DAWID1,2 has identified cytoplasmic DNA in amphibian eggs as mitochondrial DNA. This, however, does not comprise all the cytoplasmic DNA one can find in amphibian eggs. There is an important acid-soluble fraction with unknown biological function and cytological origin3,4. Leaving aside the biosynthesis of mitochondrial DNA, one wonders whether amphibian egg cytoplasmic DNA is synthesized de novo. In insect eggs, the DNA found in the ooplasm comes partly from the nurse cells which are disintegrated and incorporated into the ooplasm during oogenesis5–7. A similar phenomenon has not been observed in amphibian eggs, where the follicle cells only form a thin layer of flat cells around the oocyte. On the other hand, the amphibian oocytes are equipped with microvilli connecting the egg cortex with the surrounding follicle cells8,9. This suggests that the ingestion of foreign macromolecules occurs by pinocytosis.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Dawid, I. B., J. Mol. Biol., 12, 581 (1965).

  2. 2

    Dawid, I. B., Proc. U.S. Nat. Acad. Sci., 56, 269 (1966).

  3. 3

    Haggis, A. J., Dev. Biol., 10, 558 (1964).

  4. 4

    Løvtrup, S., Exp. Cell Res., 43, 65 (1966).

  5. 5

    Durand, M., Exp. Cell Res., 15, 257 (1958).

  6. 6

    Anderson, E., J. Cell Biol., 20, 131 (1964).

  7. 7

    Eschenberg, K. M., and Dunlap, H. L., J. Morphol., 118, 297 (1966).

  8. 8

    Balinski, B. I., and Davies, R. J., Acta Embryol. Morphol. Exp., 6, 55 (1963).

  9. 9

    Van Gansen, P., J. Embryol. Exp. Zool., 15, 255 (1966).

  10. 10

    Ficq, A., Arch. Biol., 66, 509 (1955).

  11. 11

    Ledoux, L., in Progress in Nucleic Acids Research, 4 (Academic Press, 1965).

  12. 12

    Kay, E. R. M., Nature, 191, 387 (1961).

  13. 13

    Meizel, S., and Kay, E. R. M., Biochim. Biophys. Acta, 103, 399 (1965).

  14. 14

    Sung, S.-C., and Quastel, J. H., Nature, 200, 781 (1963).

  15. 15

    Meizel, S., and Kay, E. R. M., Biochim. Biophys. Acta, 123, 34 (1966).

  16. 16

    Bendich, A., Science, 48, 374 (1965).

Download references

Author information


  1. Laboratoire de Morphologie animale, Université libre de Bruxelles

    • Y. C. KONG
    •  & A. FICQ


  1. Search for Y. C. KONG in:

  2. Search for A. FICQ in:

About this article

Publication history

Issue Date




By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.