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Early Effects of Parathyroid Hormone and Thyrocalcitonin on Bone in Organ Culture

Naturevolume 214pages486487 (1967) | Download Citation

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Abstract

BONE resorption is stimulated by parathyroid hormone (PTH), but the effect can be inhibited by actinomycin D both in vitro1,2 and in vivo2,3. These findings led to the suggestion that the action of PTH on bone depends on new RNA being synthesized. PTH, however, has a rapid and direct effect on the release of calcium ions from mitochondria which is presumably not mediated by the synthesis of new RNA4, and partial effects of PTH on the mobilization of calcium ions from bone have been detected in the presence of actinomycin D1,3,5. To clarify the relationship between the effect on the transport of calcium ions and that on the synthesis of RNA we investigated the early response of foetal bone in organ culture. The technique used also provided an opportunity to investigate the early effects of the hypocalcaemic hormone, thyrocalcitonin, which inhibits the resorption of bone in organ culture6.

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References

  1. 1

    Rasmussen, H., Arnaud, C., and Hawker, C., Science, 144, 1019 (1964).

  2. 2

    Tashijan, jun., A. H., Ontjes, D. A., and Goodfriend, T. L., Biochem. Biophys. Res. Commun., 16, 209 (1964).

  3. 3

    Raisz, L. G., Proc. Soc. Exp. Biol. and Med., 119, 614 (1965).

  4. 4

    DeLuca, H. F., Engstrom, G. W., and Rasmussen, H., Proc. U. S. Nat. Acad. Sci., 48, 1604 (1962).

  5. 5

    Talmage, R. V., Cooper, C. W., and Neuenschwander, J., Gen. Comp. Endocrinol., 5, 475 (1965).

  6. 6

    Friedman, J., and Raisz, L. G., Science, 150, 1465 (1965).

  7. 7

    Raisz, L. G., Nature, 197, 1015 (1963).

  8. 8

    Raisz, L. G., J. Clin. Invest., 44, 103 (1965).

  9. 9

    Fleck, A., and Munro, H. N., Biochim. Biophys. Acta, 55, 271 (1961).

  10. 10

    Stern, B. C., Glimcher, M. J., Mechanic, G. L., and Goldhaber, P., Proc. Soc. Exp. Biol. and Med., 119, 577 (1965).

  11. 11

    Vaes, G., Exp. Cell. Res., 39, 470 (1965).

  12. 12

    Gaillard, P. J., in The Parathyroid Glands: Ultrastructure, Secretion and Function (edit. by Gaillard, Talmage and Budy), 145 (University of Chicago Press, Chicago, Illinois, 1965).

  13. 13

    Zuli, J. E., Czarnowska-Misztal, E., and DeLuca, H. F., Proc. U.S. Nat. Acad. Sci., 55, 177 (1966).

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Affiliations

  1. Departments of Pharmacology and Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York

    • LAWRENCE G. RAISZ
    •  & INGRID NIEMANN

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https://doi.org/10.1038/214486a0

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