Letter | Published:

Loss of Chromosomes and Nondisjunction induced by Caffeine in Drosophila

Naturevolume 214page424 (1967) | Download Citation



THE mutagenic and chromosomal aberration activity of caffeine (1,3,7-trimethylxanthine) has been demonstrated in human tissue cultures1, bacteria2, Ophiostoma3, and onion root tips4. In mice the data are indeterminate5,6 and this is also the case in Drosophila because Andrew7 reported mutagenic effect of caffeine although Yanders and Seaton8 reported a lack of mutagenicity.

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  1. 1

    Ostertag, W., Duisberg, E., and Stürmann, M., Mutation Res., 2, 295 (1965).

  2. 2

    Demerec, M., Bertani, G., and Flint, J., Amer. Naturalist, 85, 119 (1951).

  3. 3

    Zetterbers, G., Hereditas, 46, 279 (1959).

  4. 4

    Kihlman, B., and Levan, A., Hereditas, 35, 109 (1949).

  5. 5

    Cattanach, B. M., Z. Vererbungslehre, 93, 215 (1962).

  6. 6

    Lyon, M. F., Phillips, J. S. R., and Searle, A. G., Z. Vererbungslehre, 93, 7 (1962).

  7. 7

    Andrew, L. E., Amer. Naturalist, 93, 135 (1959).

  8. 8

    Yanders, A. F., and Seaton, R. K., Amer. Naturalist, 96, 277 (1962).

  9. 9

    Mittler, S., and U, R., Science, 152, 1087 (1966).

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  1. Department of Biological Sciences, Northern Illinois University, DeKalb, Illinois

    •  & SALLY L. OWENS


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