Letter | Published:

Antibody Synthesis in vitro by the Rabbit Vagina against Diphtheria Toxoid

Naturevolume 214pages423424 (1967) | Download Citation



EXPERIMENTS concerned with local antibody production have resulted in a growing list of tissues where antibody synthesis has been demonstrated. The reproductive tract has been examined by several workers1–5, whose results have suggested that antibodies may be produced locally by the uterus, cervix and/or vagina. A review of the literature, however, has failed to uncover an experiment where de novo synthesis or antibody by the reproductive tract was clearly demonstrated. The present report presents evidence for the in vitro synthesis of antibody by the vagina of the rabbit after the vagina was exposed directly to the antigen in vivo. Attempts to sensitize the uterus by intrauterine injection of antigen, however, have apparently failed.

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  1. Institute of Animal Genetics, West Mains Road, Edinburgh

    • ERIC. B. BELL
  2. University of Pennsylvania, School of Veterinary Medicine, Philadelphia



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