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Antibody Synthesis in vitro by the Rabbit Vagina against Diphtheria Toxoid

Abstract

EXPERIMENTS concerned with local antibody production have resulted in a growing list of tissues where antibody synthesis has been demonstrated. The reproductive tract has been examined by several workers1–5, whose results have suggested that antibodies may be produced locally by the uterus, cervix and/or vagina. A review of the literature, however, has failed to uncover an experiment where de novo synthesis or antibody by the reproductive tract was clearly demonstrated. The present report presents evidence for the in vitro synthesis of antibody by the vagina of the rabbit after the vagina was exposed directly to the antigen in vivo. Attempts to sensitize the uterus by intrauterine injection of antigen, however, have apparently failed.

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References

  1. Batty, I., and Warrack, G. H., J. Path. Bact., 70, 355 (1955).

    Article  CAS  Google Scholar 

  2. Kerr, W. R., and Robertson, M., J. Hyg., 51, 405 (1953); Pierce, A. E., J. Comp. Path., 57, 84 (1947).

    Article  CAS  Google Scholar 

  3. Kerr, W. R., Brit. Vet. J., 111, 169 (1955).

    Article  Google Scholar 

  4. Kerr, W. R., and Robertson, M., J. Comp. Path., 57, 301 (1947).

    Article  CAS  Google Scholar 

  5. Straus, E. K., Proc. Soc. Exp. Biol. and Med., 106, 617 (1961).

    Article  CAS  Google Scholar 

  6. Stavitsky, A. B., J. Immun., 75, 214 (1955).

    CAS  PubMed  Google Scholar 

  7. Stavitsky, A. B., J. Immun., 72, 368 (1954).

    CAS  PubMed  Google Scholar 

  8. Boyden, S. V., J. Exp. Med., 93, 107 (1951).

    Article  CAS  Google Scholar 

  9. Kerr, W. R., and Robertson, M., J. Comp. Path., 53, 280 (1943).

    Article  Google Scholar 

  10. Hughes, D. E., Cornel Vet., 43, 431 (1953).

    CAS  Google Scholar 

  11. Te Punga, W. A., New Zeal. Vet. J., 7, 72 (1959).

    Article  Google Scholar 

  12. Maximow, A. A., and Bloom, W., Textbook of Histology, fifth ed., 578 (W. B. Saunders, Philadelphia and London, 1948).

    Google Scholar 

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BELL, E., WOLF, B. Antibody Synthesis in vitro by the Rabbit Vagina against Diphtheria Toxoid. Nature 214, 423–424 (1967). https://doi.org/10.1038/214423a0

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  • DOI: https://doi.org/10.1038/214423a0

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