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Intramitochondrial pH: a Statistical Question of Hydrogen Ion Concentration in a Small Element of Space-time

Naturevolume 214page400 (1967) | Download Citation



McCABE1 has argued, on statistical grounds, that the pH within mitochondria is ill-defined. In the process he asserts that water at pH 7 contains about 30 hydrogen ions per µ3, but, in fact, the value is more nearly 60 hydrogen ions per µ3 (ref. 2).

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  1. 1

    McCabe, M., Nature, 213, 280 (1967).

  2. 2

    Peters, R. A., J. State Med., 37, 1 (1929). Netter, H., Pflügers Arch. Ges. Physiol., 234, 680 (1934).

  3. 3

    Lindsay, R. B., and Margenau, H., Foundations of Physics, 178 (Wiley, New York, 1936); Hill, T. L., Thermodynamics of Small Systems, Part I, 3 (Benjamin, New York, 1963).

  4. 4

    Mitchell, P., and Moyle, J., Nature, 208, 147 (1965).

  5. 5

    Chance, B., and Mela, L., Nature, 212, 369 (1966).

  6. 6

    Eigen, M., and de Maeyer, L., Z. Elektrochem., 59, 986 (1955).

  7. 7

    Bell, R. P., The Proton in Chemistry (Methuen, London, 1959).

  8. 8

    Edsall, J. T., in Proteins, Amino Acids and Peptides (edit. by Cohn, E. J., and Edsall, J. T.), 465 (Reinhold, New York, 1943).

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    Davies, J. T., and Rideal, E. K., Interfacial Phenomena, second ed., 94 (Academic Press, New York, 1963).

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  1. Glynn Research Laboratories, Bodmin, Cornwall



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