Letter | Published:

Is there Proton Noise in Mitochondrial Membranes leading to Chance Fluctuations in pH?

Naturevolume 214pages399400 (1967) | Download Citation



IN the recent issues of Nature, there has been much “noise” about protons in mitochondrial membranes, and as a consequence it is not surprising that one of its readers should raise questions about whether noise might prevent accurate measurements of pH in the intramitochondrial space1, or indeed in any small space, such as the active site of an enzyme. The following points must not be overlooked in such a consideration.

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  1. 1

    McCabe, M., Nature, 213, 280 (1967).

  2. 2

    Eigen, M., Faraday Soc. Disc., 19, 203 (1954).

  3. 3

    Ingelfritz, A., dissertation, Univ. Goettingen (1966).

  4. 4

    Chance, B., and Legallais, V., Rev. Sci. Instrum., 30, 735 (1959).

  5. 5

    Chance, B., J. Franklin Inst., 282, 349 (1966).

  6. 6

    Williams, jun., A. J., Tarpley, R. E., and Clark, W. R., Trans. Amer. Inst. Elect. Engineers, 67, 1 (1948).

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  1. Johnson Research Foundation, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania



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