Letter | Published:

Potentiation of Adenosine by Dipyridamole

Naturevolume 214pages390391 (1967) | Download Citation



DIPYRIDAMOLE [2,6-bis(diethanolamino)-4,8-dipiperidino-pyrimido (5,4-d)pyrimidine] dilates the coronary vessels, and is used to treat angina1. Dipyridamole also changes the metabolism of adenosine and adenine nucleotides in cardiac muscle2–4. This action is clear in hypoxic hearts, in which dipyridamole decreases the loss of adenosine2 and adenosine triphosphate (ATP)3. Adenosine and adenine nucleotides dilate the coronary vessels but there is not yet sufficient evidence to prove that the coronary dilator action of dipyridamole is caused by alteration of nucleotide metabolism.

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    Present address: Victorian College of Pharmacy, 381 Royal Parade, Parkville, N.2, Victoria, Australia


  1. Department of Pharmacology, London Hospital Medical College, Turner Street, E.1.



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