Letter | Published:

Action of Thyrocalcitonin on Bone

Naturevolume 214pages388389 (1967) | Download Citation

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Abstract

A CONSIDERABLE amount of evidence has been presented which suggests that thyrocalcitonin, the hypocalcemic, hypophosphatemic hormone first described by Hirsch et al.1, promotes the deposition of calcium in bone. Aliapoulias et al.2 indicated that in tissue culture, thyrocalcitonin exerted a direct positive effect on the deposition of calcium into mouse calvariae. Foster et al.3 have also recently indicated that thyrocalcitonin promoted calcium uptake by perfused isolated bone. Investigations from these laboratories4 indicated that perfusion of rats over a period of 1 h with thyrocalcitonin and calcium-45 resulted in an increased isotopic concentration in the bones as compared to the isotopic concentration of the bones of rats perfused with calcium-45 only. Further, we4 have demonstrated that the administration of thyrocalcitonin to rats over a period of 5 days led to an increased positive calcium balance and a reduction of endogenous calcium.

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References

  1. 1

    Hirsch, P. F., Gauthier, G. F., and Munson, P. L., Endocrinology, 73, 244 (1963).

  2. 2

    Aliapoulias, M. A., Goldhaber, P., and Munson, P. L., Science, 151, 330 (1966).

  3. 3

    Foster, G. V., Joplin, G. F., Maclntyre, I., Melvin, K. E. W., and Slack, E., Lancet, i, 107 (1966).

  4. 4

    Wase, A. W., Peterson, A., Rickes, E., and Solewski, J., Endocrinology (in the press).

  5. 5

    Kenny, A. D., and Heiskell, C. A., Proc. Soc. Exp. Biol. and Med. 120, 269 (1965).

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    Gudmundsson, T. V., MacIntyre, I., and Soliman, H. A., Proc. Roy. Soc., B, 164, 460 (1966).

  7. 7

    Milch, R. A., Roll, D. P., and Tobie, J. E., J. Bone Jt. Surg., 40A, 897 (1958).

  8. 8

    Hirsch, P. F., Voekel, E. F., and Munson, P. L., Science, 146, 412 (1964).

  9. 9

    Tennenhause, A., Arnaud, C., and Rasmussen, H., Proc. U.S. Nat. Acad. Sci., 53, 818 (1965).

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Affiliations

  1. Merck Institute for Therapeutic Research, Rahway, New Jersey

    • A. W. WASE
    • , J. SOLEWSKI
    • , E. RICKES
    •  & J. SEIDENBERG

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https://doi.org/10.1038/214388a0

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