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Influence of Anti-rheumatic Drugs on Urinary Excretion of Hydroxyproline in Lathyrism

Naturevolume 214page384 (1967) | Download Citation

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Abstract

LATHYROGENIC agents in the diet of several animal species induced an increase in the soluble collagen fractions present in various tissues, with a parallel increase in the hydroxyproline peptides excreted in the urine1–3. Simultaneous administration of hydrocortisone to rats on a diet of Lathyrus odoratus partially reduced the increased amount of neutral salt soluble collagen in skin4; although sodium salicylate was more effective than hydrocortisone. The present investigation was undertaken to ascertain whether the simultaneous treatment of lathyritic rats with anti-rheumatic drugs influenced the increased concentration of hydroxyproline in the urine.

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Affiliations

  1. Research Institute for Rheumatic Diseases, Piešťany, Czechoslovakia

    • Z. TRNAVSKÁ
    •  & K. TRNAVSKÝ

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https://doi.org/10.1038/214384a0

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