Abstract
Peculiar vesicular structures in the axons and synaptic terminals of neocortex of a 30 month old boy with psychomotor retardation of unknown origin are similar to the changes observed in other human diseases characterized by disorders of memory and learning. Such changes in the architecture of axons and synapses may cause certain disorders the aetiology of which is at present obscure.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Eccless, J. C., The Physiology of Synapses (Academic Press, Inc., New York, 1964).
Koells, G. B., in Evolution of Nervous Control (edit. by Bass, A. D.), 87 (American Association for the Advancement of Science, Washington, 1959).
DeRobertis, E., and Bennett, H. S., Fed. Proc., 13, 35 (1954).
Palay, S. L., Anat. Rec., 118, 193 (1954).
Palade, G. E., Anat. Rec., 118, 335 (1954).
DeRobertis, E., Lores Arnaiz, G. R., Salganicoff, L., Pellegrino De Iraldi, A., and Zieher, L. M., J. Neurochem., 10, 225 (1963).
Whittaker, V. P., and Sheridan, M. N., J. Neurochem., 12, 363 (1965).
Richardson, K. C., Amer. J. Anat., 114, 173 (1964).
DeRobertis, E., in Histophysiology of Synapses and Neurosecretion, 1, 27 (The Macmillan Company, New York, and Pergamon Press, Oxford, 1960).
Weiss, P., Fourth Intern. Neurochem. Symp., 2, 220 (Pergamon Press, New York, 1960).
Van der Loos, H., Z. Zellforsch., 60, 815 (1963).
Pappas, G. D., and Purpura, D. P., Nature, 210, 1391 (1966).
Palay, S. L., J. Biophys. Biochem. Cytol. Suppl., 2, 193 (1956).
Gray, E. G., J. Anat. London, 96, 420 (1959).
Pappas, G. D., Exp. Neurol., 4, 507 (1961).
Boycott, B. B., Gray, E. G., and Guillery, R. W., J. Physiol., 152, 3P (1960).
Gonatas, N. K., and Goldensohn, E. S., J. Neuropath. and Exp. Neurol., 24, 539 (1965).
Gonatas, N. K., Anderson, W., and Evangelista, I., J. Neuropath. and Exp. Neurol., 26, 25 (1967).
Hebb, D. W., Organization of Behaviour. A Neuro-physiological Study (John Wiley and Sons, Inc., New York, 1957).
Elul, R., Nature, 210, 5041 (1966).
Baker, J. R., Quart. J. Micros. Sci., 87, 441 (1946).
Sabatini, D. D., Bensch, K., and Barrnett, R. J., J. Cell Biol., 17, 19 (1963).
Gomori, G., Microscopic Histochemistry, Principles and Practice, 182 (University of Chicago Press, 1952).
Novikoff, A. B., and Goldfisher, S., Proc. U.S. Nat. Acad. Sci., 47, 802 (1961).
Novikoff, A. B., Shin, N. Y., and Drucker, J., J. Biophys. Biochem. Cytol., 9, 47 (1960).
Gonatas, N. K., and Robbins, E., Protoplasma, 59, 25 (1964).
Smith, C. A., and Rasmussen, C. L., J. Cell Biol., 26, 63 (1965).
Dowling, D. E., and Cowan, W. M., Z. Zellforsch., 71, 14 (1966).
Gray, E. G., and Hamlyn, L. H., J. Anat. Lond., 96, 309 (1962).
Colonnier, M., and Guillery, R. W., Z. Zellforsch., 62, 333 (1964).
Colonnier, M., and Gray, E. G., Degeneration in the Cerebral Cortex, 3, 2 (edit. by Breese, S. S.) (Academic Press, New York, 1962).
Colonnier, M., J. Anat., Lond., 98, 47 (1964).
Walberg, F., Exp. Neurol., 8, 112 (1963).
Walberg, F., J. Comp. Neurol., 122, 113 (1964).
Smith, J. M., O'Learny, J. L., Harris, A. B., and Gay, A. J., J. Comp. Neurol., 123, 357 (1964).
Webster, De F. H., J. Cell Biol., 12, 361 (1962).
Thomas, P. K., and Sheldon, H., J. Cell Biol., 22, 715 (1964).
Barton, A. A., Brain, 85, 799 (1962).
Lee, J. C.-Y., J. Comp. Neurol., 120, 65 (1963).
Nathaniel, E. J. H., and Pease, D. C., J. Ultrastruct. Res., 9, 511 (1963).
Terry, R. D., and Harkin, J. C., in The Biology of Myelin, 303 (edit. by Korey, S. A.) (Paul B. Hoeber, New York, 1959).
Ohmi, S., Z. Zellforsch., 54, 39 (1961).
Lambert, P., Bluemberg, T. M., and Pentschew, A., J. Neuropath. Neurol., 23, 60 (1964).
Gowen, D., and Olmstead, E. V., J. Neuropath. Exp. Neurol., 22, 175 (1963).
Seitelberger, F., in Proc. First Intern. Cong. Neuropath. (Rome, September 8–13, 1952), 3, 323 (Rosenberg and Sellier, Turin, 1952).
Hodgkin, A. L., The Conduction of the Nervous Impulse. The Sherrington Lectures VII (Charles C. Thomas, Springfield, 1964).
Ledbetter, M. D., and Porter, K. R., J. Cell Biol., 19, 239 (1963).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GONATAS, N. Axonic and Synaptic Lesions in Neuropsychiatric Disorders. Nature 214, 352–355 (1967). https://doi.org/10.1038/214352a0
Issue Date:
DOI: https://doi.org/10.1038/214352a0
This article is cited by
-
Cell response of the olfactory bulb to ionizing radiation injury
Acta Neuropathologica (1971)
-
Electron microscopic study on a case of idiocy: Astrocytes and mental deficiency
Acta Neuropathologica (1970)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.