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Axonic and Synaptic Lesions in Neuropsychiatric Disorders

Abstract

Peculiar vesicular structures in the axons and synaptic terminals of neocortex of a 30 month old boy with psychomotor retardation of unknown origin are similar to the changes observed in other human diseases characterized by disorders of memory and learning. Such changes in the architecture of axons and synapses may cause certain disorders the aetiology of which is at present obscure.

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References

  1. Eccless, J. C., The Physiology of Synapses (Academic Press, Inc., New York, 1964).

    Book  Google Scholar 

  2. Koells, G. B., in Evolution of Nervous Control (edit. by Bass, A. D.), 87 (American Association for the Advancement of Science, Washington, 1959).

    Google Scholar 

  3. DeRobertis, E., and Bennett, H. S., Fed. Proc., 13, 35 (1954).

    Google Scholar 

  4. Palay, S. L., Anat. Rec., 118, 193 (1954).

    Google Scholar 

  5. Palade, G. E., Anat. Rec., 118, 335 (1954).

    Google Scholar 

  6. DeRobertis, E., Lores Arnaiz, G. R., Salganicoff, L., Pellegrino De Iraldi, A., and Zieher, L. M., J. Neurochem., 10, 225 (1963).

    Article  CAS  Google Scholar 

  7. Whittaker, V. P., and Sheridan, M. N., J. Neurochem., 12, 363 (1965).

    Article  CAS  Google Scholar 

  8. Richardson, K. C., Amer. J. Anat., 114, 173 (1964).

    Article  CAS  Google Scholar 

  9. DeRobertis, E., in Histophysiology of Synapses and Neurosecretion, 1, 27 (The Macmillan Company, New York, and Pergamon Press, Oxford, 1960).

    Google Scholar 

  10. Weiss, P., Fourth Intern. Neurochem. Symp., 2, 220 (Pergamon Press, New York, 1960).

    Google Scholar 

  11. Van der Loos, H., Z. Zellforsch., 60, 815 (1963).

    Article  CAS  Google Scholar 

  12. Pappas, G. D., and Purpura, D. P., Nature, 210, 1391 (1966).

    Article  ADS  CAS  Google Scholar 

  13. Palay, S. L., J. Biophys. Biochem. Cytol. Suppl., 2, 193 (1956).

    Article  CAS  Google Scholar 

  14. Gray, E. G., J. Anat. London, 96, 420 (1959).

    Google Scholar 

  15. Pappas, G. D., Exp. Neurol., 4, 507 (1961).

    Article  CAS  Google Scholar 

  16. Boycott, B. B., Gray, E. G., and Guillery, R. W., J. Physiol., 152, 3P (1960).

    Google Scholar 

  17. Gonatas, N. K., and Goldensohn, E. S., J. Neuropath. and Exp. Neurol., 24, 539 (1965).

    Article  CAS  Google Scholar 

  18. Gonatas, N. K., Anderson, W., and Evangelista, I., J. Neuropath. and Exp. Neurol., 26, 25 (1967).

    Article  CAS  Google Scholar 

  19. Hebb, D. W., Organization of Behaviour. A Neuro-physiological Study (John Wiley and Sons, Inc., New York, 1957).

    Google Scholar 

  20. Elul, R., Nature, 210, 5041 (1966).

    Article  Google Scholar 

  21. Baker, J. R., Quart. J. Micros. Sci., 87, 441 (1946).

    CAS  Google Scholar 

  22. Sabatini, D. D., Bensch, K., and Barrnett, R. J., J. Cell Biol., 17, 19 (1963).

    Article  CAS  Google Scholar 

  23. Gomori, G., Microscopic Histochemistry, Principles and Practice, 182 (University of Chicago Press, 1952).

    Google Scholar 

  24. Novikoff, A. B., and Goldfisher, S., Proc. U.S. Nat. Acad. Sci., 47, 802 (1961).

    Article  ADS  CAS  Google Scholar 

  25. Novikoff, A. B., Shin, N. Y., and Drucker, J., J. Biophys. Biochem. Cytol., 9, 47 (1960).

    Article  Google Scholar 

  26. Gonatas, N. K., and Robbins, E., Protoplasma, 59, 25 (1964).

    Google Scholar 

  27. Smith, C. A., and Rasmussen, C. L., J. Cell Biol., 26, 63 (1965).

    Article  CAS  Google Scholar 

  28. Dowling, D. E., and Cowan, W. M., Z. Zellforsch., 71, 14 (1966).

    Article  CAS  Google Scholar 

  29. Gray, E. G., and Hamlyn, L. H., J. Anat. Lond., 96, 309 (1962).

    CAS  Google Scholar 

  30. Colonnier, M., and Guillery, R. W., Z. Zellforsch., 62, 333 (1964).

    Article  CAS  Google Scholar 

  31. Colonnier, M., and Gray, E. G., Degeneration in the Cerebral Cortex, 3, 2 (edit. by Breese, S. S.) (Academic Press, New York, 1962).

    Google Scholar 

  32. Colonnier, M., J. Anat., Lond., 98, 47 (1964).

    CAS  PubMed  Google Scholar 

  33. Walberg, F., Exp. Neurol., 8, 112 (1963).

    Article  Google Scholar 

  34. Walberg, F., J. Comp. Neurol., 122, 113 (1964).

    Article  Google Scholar 

  35. Smith, J. M., O'Learny, J. L., Harris, A. B., and Gay, A. J., J. Comp. Neurol., 123, 357 (1964).

    Article  CAS  Google Scholar 

  36. Webster, De F. H., J. Cell Biol., 12, 361 (1962).

    Article  CAS  Google Scholar 

  37. Thomas, P. K., and Sheldon, H., J. Cell Biol., 22, 715 (1964).

    Article  CAS  Google Scholar 

  38. Barton, A. A., Brain, 85, 799 (1962).

    Article  CAS  Google Scholar 

  39. Lee, J. C.-Y., J. Comp. Neurol., 120, 65 (1963).

    Article  CAS  Google Scholar 

  40. Nathaniel, E. J. H., and Pease, D. C., J. Ultrastruct. Res., 9, 511 (1963).

    Article  Google Scholar 

  41. Terry, R. D., and Harkin, J. C., in The Biology of Myelin, 303 (edit. by Korey, S. A.) (Paul B. Hoeber, New York, 1959).

    Google Scholar 

  42. Ohmi, S., Z. Zellforsch., 54, 39 (1961).

    Article  CAS  Google Scholar 

  43. Lambert, P., Bluemberg, T. M., and Pentschew, A., J. Neuropath. Neurol., 23, 60 (1964).

    Article  Google Scholar 

  44. Gowen, D., and Olmstead, E. V., J. Neuropath. Exp. Neurol., 22, 175 (1963).

    Article  Google Scholar 

  45. Seitelberger, F., in Proc. First Intern. Cong. Neuropath. (Rome, September 8–13, 1952), 3, 323 (Rosenberg and Sellier, Turin, 1952).

    Google Scholar 

  46. Hodgkin, A. L., The Conduction of the Nervous Impulse. The Sherrington Lectures VII (Charles C. Thomas, Springfield, 1964).

    Google Scholar 

  47. Ledbetter, M. D., and Porter, K. R., J. Cell Biol., 19, 239 (1963).

    Article  CAS  Google Scholar 

Download references

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GONATAS, N. Axonic and Synaptic Lesions in Neuropsychiatric Disorders. Nature 214, 352–355 (1967). https://doi.org/10.1038/214352a0

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