Letter | Published:

“Curling's Ulcer” in the Germfree Mouse

Naturevolume 214pages298299 (1967) | Download Citation

Subjects

Abstract

Artz and Fitts1 reviewed the present state of knowledge about the pathogenesis of gastrointestinal ulcerations associated with lesions of the central nervous system and with burns. They concluded that “It would seem that at the present time, despite intensive investigation over many years, the exact method by which a cutaneous burn induces gastrointestinal lesions is unknown”. There are, however, a number of theories about the mechanism(s) responsible for upper gastrointestinal ulceration and bleeding after burns2–4. The present communication deals with some questions related to the still unresolved problem of the importance of microbial factors and of infection and sepsis1–3,5,6 to the development of gastric ulcers after burns. In the course of studying experimental dorsal burns in germfree and “conventionalized” (multicontaminated ex-germfree) mice, we have discovered that germfree mice develop gastric lesions soon after scalding and that the incidence of these lesions is similar to that in their conventional counterparts.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Artz, C. P., and Fitts, C. T., Surg. Clin. N. Amer., 46, 309 (1966).

  2. 2

    Harkins, H. H., Surgery, 3, 608 (1938).

  3. 3

    Friesen, S. R., Surgery, 28, 123 (1950).

  4. 4

    Foss, D. L., Stavney, S., Haraguchi, T., Harkins, H. N., and Nyhus, L. M., J. Amer. Med. Assoc., 187, 592 (1964).

  5. 5

    Hartman, F. W., Gastroenterology, 6, 130 (1946).

  6. 6

    Moncrief, J. A., Switzer, W. E., and Teplitz, C., J. Trauma, 6, 481 (1966).

  7. 7

    Einheber, A., and Carter, D., J. Exp. Med., 123, 239 (1966).

Download references

Author information

Affiliations

  1. Department of Germfree Research, Division of Surgery, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington

    • ALBERT EINHEBER
    • , ROBERT E. WREN
    • , RODNEY F. PORRO
    •  & ARTHUR S. DOBEK

Authors

  1. Search for ALBERT EINHEBER in:

  2. Search for ROBERT E. WREN in:

  3. Search for RODNEY F. PORRO in:

  4. Search for ARTHUR S. DOBEK in:

About this article

Publication history

Issue Date

DOI

https://doi.org/10.1038/214298a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.