Letter | Published:

Features of Antibody Formation in Neonatally Thymectomized Mice

Naturevolume 214pages295297 (1967) | Download Citation



THE production of antibody to some antigens is suppressed in neonatally thymectomized mice1–3. A dissociation of immunological reactivity in such mice has been established4,5. The primary response is inhibited to sheep erythrocytes but is retained to live influenza virus and typhoid Vi-antigen. Re-immunization of neonatally thymectomized mice restored the normal formation of antibody to sheep erythrocytes4,5. In thymectomized mice, in which immunological reactivity has been recovered by re-immunization, the regional lymphatic nodes restore their normal histological patterns. Zinzar6 has demonstrated that neonatally thymectomized mice can also produce antibody to sheep erythrocytes after primary immunization. In this case, antibody production begins later, but continues for a longer time than is normal. Antibody titres can be even higher than in normal animals. Sinclair7 has obtained very similar results, but in his experiments the antibodies to sheep erythrocytes in thymectomized mice never reached the titres of normal mice.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Miller, J. F. A. P., Lancet, ii, 748 (1961).

  2. 2

    Miller, J. F. A. P., Lancet, ii, 43 (1963).

  3. 3

    Waksman, B. H., Arnason, B. G., and Jankowic, B. D., J. Exp. Med., 116, 159 (1962).

  4. 4

    Svet-Moldavsky, G. J., Zinzar, S. N., and Egorkina, D. A., in Second Meeting Microbiol. Epidemiol. Latvian S.S.R., Riga, 149 (1963).

  5. 5

    Svet-Moldavsky, G. J., Zinzar, S. N., and Spector, N. M., Nature, 202, 353 (1964).

  6. 6

    Zinzar, S. N., Abstr. Meeting Gen. Immunol., Moscow, 12 (1965).

  7. 7

    Sinclair, N. R., Nature, 208, 1104 (1965).

  8. 8

    Ravkina, L. J., Zinzar, S. N., and Svet-Moldavsky, G. J., Abstr. Meeting Gen. Immunol., Moscow, 11 (1965).

  9. 9

    Nossal, G. J. V., Austral. J. Exp. Biol. and Med. Sci., 37, 499 (1959).

  10. 10

    Taliaferro, W. H., and Taliaferro, L. G., J. Inf. Disease, 114, 285 (1964).

  11. 11

    Svet-Moldavsky, G. J., Nature, 209, 933 (1966).

Download references

Author information


  1. Laboratory of Virology, Institute of Experimental and Clinical Oncology, Moscow



  1. Search for SVETLANA N. ZINZAR in:

  2. Search for GEORGE J. SVET-MOLDAVSKY in:

About this article

Publication history

Issue Date




By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.