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Induction of 19S Antibody Synthesis without Stimulation of Cellular Proliferation

Naturevolume 214pages293295 (1967) | Download Citation



ANTIGEN evokes a heterogeneous immunoglobulin response in which each molecular species is probably synthesized by a different cell population1,2. Although recent reports3–8 have suggested that antigen stimulates both proliferation and antibody synthesis in the same lymphoid cell, these two functions may not necessarily be associated in all the types of cells which respond to antigen. This possibility was examined in cells making 19S antibody—one of the four antibody classes known in the mouse9.

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  1. 1

    Mellors, R. C., and Korngold, L., J. Exp. Med., 118, 387 (1963).

  2. 2

    Bernier, G. M., and Cebra, J. J., J. Immunol., 95, 246 (1965).

  3. 3

    Nossal, G. J. V., Mitchell, J., and McDonald, W., Austral. J. Exp. Biol., 41, 423 (1963).

  4. 4

    Nossal, G. J. V., and Makela, O., J. Exp. Med., 115, 209 (1962).

  5. 5

    Makela, O., and Nossal, G. J. V., J. Exp. Med., 115, 231 (1962).

  6. 6

    Schooley, J. C., J. Immunol., 86, 331 (1961).

  7. 7

    Cohen, E. P., and Talmage, D. W., J. Exp. Med., 121, 125 (1965).

  8. 8

    Baney, R. N., Vazquez, J. J., and Dixon, F. J., Proc. Soc. Exp. Biol. and Med., 109, 1 (1962).

  9. 9

    Fahey, J. L., Wunderlich, J., and Mishell, R., J. Exp. Med., 120, 223 (1964).

  10. 10

    Jerne, N. K., Nordin, A., and Henry, C., in Cell Bound Antibodies (edit. by Amos, B., and Koprowski, H.,) 109 (Wistar Institute Press, Philadelphia, 1963).

  11. 11

    Jerne, N. K., Nordin, A., Henry, C., Funi, H., and Koros, A., Inf. Exchange Group No. 5 (Immunopathol.) Memo No. 46 (September 27, 1965).

  12. 12

    Little, J. R., Brecher, G., Bradley, T. R., and Rose, S., Blood, 19, 236 (1962).

  13. 13

    Hughes, W. L., Bond, V. P., Brecher, G., Cronkite, E. P., Painter, R. B., Quastler, H., and Sherman, F. G., Proc. U.S. Nat. Acad. Sci., 44, 476 (1958).

  14. 14

    Palt, H. M., and Maloney, M. A., in The Kinetics of Cellular Proliferation (edit. by Stohlman, F.), 201 (Grune and Stratton, New York, 1959).

  15. 15

    Cronkite, E. P., Fliedner, T. M., Bond, V. P., and Rubini, J. R., Ann. N.Y. Acad. Sci., 77, 803 (1959).

  16. 16

    Bryant, B., and Kelly, L. S., Univ. Cal. Rad. Lab. Biol. and Med. Quart. Rep. UCRL, 3653, 36 (January 1957).

  17. 17

    Bryant, B., and Kelly, L. S., Proc. Soc. Exp. Biol. and Med., 99, 681 (1958).

  18. 18

    Sterzl, J., Nature, 189, 1022 (1961).

  19. 19

    Svehag, S., and Mandel, B., J. Exp. Med., 119, 21 (1964).

  20. 20

    Leduc, E. H., Coons, A. H., and Connoly, J. M., J. Exp. Med., 102, 61 (1955).

  21. 21

    Monod, J., and Cohn, M., Adv. in Enzymol., 13, 67 (1952).

  22. 22

    Cohn, M., Bacteriol. Rev., 21, 140 (1957).

  23. 23

    Sterzl, J., Vesely, J., Jilek, M., and Mandel, L., in Molecular and Cellular Basis of Antibody Formation (edit. by Sterzl, J.), 463 (Academic Press, New York, 1965).

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  1. Section of Clinical Immunology, New England Medical Center Hospitals, Boston, Massachusetts



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