Letter | Published:

Antigen Deletions in Carcinogen-induced Rat Hepatomata

Naturevolume 214pages292293 (1967) | Download Citation



NORMAL tissue antigens have frequently been shown to be absent from experimentally induced tumours. Thus immunohistological studies have shown the loss of kidney antigens in, stilboestrol and X-ray induced kidney tumours1,2, of skin antigens in 3-methylcholanthrene-induced mouse squamous cell carcinomata3 and certain muscle antigens in 3-methylcholanthrene-induced rat rhabdomyosarcomata4. By far the most extensively studied class of tumours are the chemically induced hepatomata where deletion of liver antigens has been shown in tumours induced with 4-dimethylaminoazobenzene5–7, diethylnitrosamine8 and 2-acetamidofluorene9 in the rat and o-aminoazotoluene in the mouse10. Previous studies5 denned the number and subcellular distribution of normal rat liver antigens deleted from primary hepatomata induced with 4-dimethylaminoazobenzene. These studies have been extended to compare the pattern of antigen deletions in rat hepatomata induced with 2-acetamidofluorene and diethylnitrosamine using both primary and transplanted tumours.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Nairn, R. C., Richmond, H. G., McEntegart, M. G., and Fothergill, J. E., Brit. Med. J., ii, 1335 (1960).

  2. 2

    Deckers, C., Structure Antigénique de Tumeurs Expérimentales (Éditions Arscia S.A., Brussels, 1964).

  3. 3

    Carruthers, C., and Baumler, A., J. Nat. Cancer Inst., 34, 191 (1965).

  4. 4

    Fel, V. J., and Tsikarishvili, T. N., Cancer Res., 24, 1675 (1964).

  5. 5

    Baldwin, R. W., Brit. J. Cancer, 18, 285 (1964).

  6. 6

    Deckers, C., and Maisin, J., Rev. Belg. Path. Med. Exp., 28, 477 (1962).

  7. 7

    Kalnins, V. I., and Stich, H. F., Nature, 200, 189 (1963).

  8. 8

    Fel, V. J., Tsikarishvili, T. N., and Shvemberger, I. N., Vopr. Onkol., 10, 66 (1964).

  9. 9

    Hiramoto, R., Bernecky, J., Jurandowski, J., and Pressman, D., Cancer. Res., 21, 1372 (1961).

  10. 10

    Abelev, G. I., Khramkova, N. I., and Postnikova, Z. A., Neoplasma, 9, 123 (1962).

  11. 11

    Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. Biol. Chem., 193, 265 (1951).

  12. 12

    Woodruff, M. F. A., and Symes, M. O., Brit. J. Cancer, 16, 484 (1962).

  13. 13

    Freed, J. J., and Sorof, S., Biochem. Biophys. Res. Commun., 22, 1 (1966).

  14. 14

    Sachs, L., Nature, 207, 1272 (1965).

  15. 15

    Kitagawa, M., Yagi, Y., Planinsek, J., and Pressman, D., Cancer Res., 26, 221 (1966).

Download references

Author information


  1. British Empire Cancer Campaign Research Laboratory, University of Nottingham

    • R. W. BALDWIN
    •  & C. R. BARKER


  1. Search for R. W. BALDWIN in:

  2. Search for C. R. BARKER in:

About this article

Publication history

Issue Date




By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.