Letter | Published:

Antigen Deletions in Carcinogen-induced Rat Hepatomata

Naturevolume 214pages292293 (1967) | Download Citation

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Abstract

NORMAL tissue antigens have frequently been shown to be absent from experimentally induced tumours. Thus immunohistological studies have shown the loss of kidney antigens in, stilboestrol and X-ray induced kidney tumours1,2, of skin antigens in 3-methylcholanthrene-induced mouse squamous cell carcinomata3 and certain muscle antigens in 3-methylcholanthrene-induced rat rhabdomyosarcomata4. By far the most extensively studied class of tumours are the chemically induced hepatomata where deletion of liver antigens has been shown in tumours induced with 4-dimethylaminoazobenzene5–7, diethylnitrosamine8 and 2-acetamidofluorene9 in the rat and o-aminoazotoluene in the mouse10. Previous studies5 denned the number and subcellular distribution of normal rat liver antigens deleted from primary hepatomata induced with 4-dimethylaminoazobenzene. These studies have been extended to compare the pattern of antigen deletions in rat hepatomata induced with 2-acetamidofluorene and diethylnitrosamine using both primary and transplanted tumours.

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Affiliations

  1. British Empire Cancer Campaign Research Laboratory, University of Nottingham

    • R. W. BALDWIN
    •  & C. R. BARKER

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https://doi.org/10.1038/214292a0

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