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Protein and Nucleic Acid Synthesis in Lymph Node Cells of Thymectomized Rats undergoing a Primary Immune Response

Naturevolume 214pages289291 (1967) | Download Citation



NEONATAL thymectomy in rats has been shown to impair the immunological response to certain antigenic stimuli. Measurements of this impairment have been based on the inability of lymphocytes from neonatally thymectomized animals to elicit normal homograft or graft versus host reactions1,2. Other investigators noted alterations in circulating plasma proteins after neonatal thymectomy3. These alterations, however, did not occur in either IgM or IgG fractions generally believed to be responsible for many antibody–antigen reactions.

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  1. Department of Biological Structure, University of Washington, School of Medicine, Seattle, Washington



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