Abstract
NEONATAL thymectomy in rats has been shown to impair the immunological response to certain antigenic stimuli. Measurements of this impairment have been based on the inability of lymphocytes from neonatally thymectomized animals to elicit normal homograft or graft versus host reactions1,2. Other investigators noted alterations in circulating plasma proteins after neonatal thymectomy3. These alterations, however, did not occur in either IgM or IgG fractions generally believed to be responsible for many antibody–antigen reactions.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Rieke, W. O., Science, 152, 535 (1966).
Arnason, B. G., Janković, B. D., Waksman, B. H., and Wennersten, C., J. Exp. Med., 116, 177 (1962).
Arnason, B. G., de Vaux St-Cyr, C., and Relyveld, E. H., Intern. Arch. Allergy, 25, 206 (1964).
Porter, K. A., and Cooper, E. H., Lancet, ii, 317 (1962).
Gowans, J. L., McGregor, D. D., Cowan, D. M., and Ford, L. E., Nature, 196, 651 (1962).
Rieke, W. O., Everett, N. B., and Caffrey, R. W., Acta Haem., 30, 103 (1963).
Ceriotti, G., J. Biol. Chem., 198, 297 (1952).
Mejbaum, W., Physiol. Chem., 258, 117 (1939).
Slonecker, C. E., and Rieke, W. O., Nature, 207, 729 (1965).
Epstein, L. B., and Stohlman, F., Blood, 24, 69 (1964).
Zucker-Franklin, D., Franklin, E. G., and Cooper, N. S., Blood, 20, 56 (1962).
Ortega, L. G., and Mellors, R. C., J. Exp. Med., 106, 627 (1957).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SLONECKER, C., RIEKE, W. Protein and Nucleic Acid Synthesis in Lymph Node Cells of Thymectomized Rats undergoing a Primary Immune Response. Nature 214, 289–291 (1967). https://doi.org/10.1038/214289a0
Issue Date:
DOI: https://doi.org/10.1038/214289a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.