Letter | Published:

Differences in Uridine Diphosphate Galactose-4-Epimerase between Haemolysates of Newborns and of Adults

Naturevolume 214pages283284 (1967) | Download Citation



THIS communication presents an observation not yet reported concerning the effect of exogenous nicotinamide adenine dinucleotide (NAD) on the activity of uridine diphosphate galactose-4-epimerase. This enzyme (formerly called galactowaldenase) was first demonstrated in yeast extract by Leloir1. NAD was shown later to be required for activity in a calf liver preparation2. The need for an exogenous supply of NAD was further shown in crude human haemolysates3 and in homogenates of L cells4. It now has been found that haemolysates from newborn infants demonstrate a substantial epimerase activity without the addition of NAD.

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  1. Departments of Biochemistry and of Pediatrics of the School of Medicine, University of Southern California. Children's Hospital of Los Angeles. Los Angeles County General Hospital

    • WON G. NG


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