Abstract
THIS communication presents an observation not yet reported concerning the effect of exogenous nicotinamide adenine dinucleotide (NAD) on the activity of uridine diphosphate galactose-4-epimerase. This enzyme (formerly called galactowaldenase) was first demonstrated in yeast extract by Leloir1. NAD was shown later to be required for activity in a calf liver preparation2. The need for an exogenous supply of NAD was further shown in crude human haemolysates3 and in homogenates of L cells4. It now has been found that haemolysates from newborn infants demonstrate a substantial epimerase activity without the addition of NAD.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Leloir, L. F., Arch. Biochem. Biophys., 33, 186 (1951).
Maxwell, E. S., J. Amer. Chem. Soc., 78, 1074 (1956).
Isselbacher, K. J., Anderson, E. P., Kurahashi, K., and Kalckar, H. M., Science, 123, 635 (1956).
Robinson, E. A., Kalckar, H. M., and Troedsson, H., Biochem. Biophys. Res. Commun., 13, 313 (1963).
Ng, W. G., Donnell, G. N., and Bergren, W. R., J. Lab. Clin. Med., 66, 115 (1965).
Kabacy, G., Hodgman, J., Donnell, G. N., and Spears, R., Pediatrics, 38, 125 (1966).
Horecker, B. L., and Kornberg, A., J. Biol. Chem., 175, 385 (1948).
Gross, R. T., Schroeder, E. A., and Gabrio, B. W., J. Clin. Invest., 45, 249 (1966).
Rubinstein, E., Ottolenghi, P., and Denstedt, O. F., Canad. J. Biochem. Physiol., 34, 222 (1956).
Gasiorowska, I., and Racznska-Bojanowska, K., Bull. Acad. Polon. Sci., 11, 417 (1963).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
NG, W., DONNELL, G., HODGMAN, J. et al. Differences in Uridine Diphosphate Galactose-4-Epimerase between Haemolysates of Newborns and of Adults. Nature 214, 283–284 (1967). https://doi.org/10.1038/214283a0
Issue Date:
DOI: https://doi.org/10.1038/214283a0
This article is cited by
-
Analysis of UDP‐galactose 4′‐epimerase mutations associated with the intermediate form of type III galactosaemia
Journal of Inherited Metabolic Disease (2008)
-
A geographic approach to senile cataracts
Digestive Diseases and Sciences (1982)
-
Deficiency of Erythrocyte Nicotinamide Adenine Dinucleotide Nucleosidase (NADase) Activity in the Negro
Nature (1968)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
