Letter | Published:

Isolation of a Non-dialysable Active Pressor Principle from Pig Serum

Naturevolume 214page279 (1967) | Download Citation



A NON-DIALYSABLE hypertensive substance stable to heat is found in rat serum after incubation at 37° C (refs. 1 and 2). The same activity can be demonstrated in the serum and plasma of human beings, pigs and rabbits, but not of frogs3. The blood pressure response to this active pressor principle (APP) was demonstrated in rats during an infusion of hypotonic glucose and compared with the hypertensive effect of synthetic angiotensin1. Because APP seems to be different from known hypertensive polypeptides and renin1, further purification of it is of interest.

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  1. 1

    Kenner, Th., and Waldhäusl, W., Nature, 204, 581 (1964).

  2. 2

    Khairallah, P. A., and Page, I. H., Amer. J. Physiol., 119, 341 (1960).

  3. 3

    Waldhäusl, W., and Kenner, Th., Med. Pharmacol. Exp., 12, 388 (1965).

  4. 4

    Croxatto, H., in Perspectives in Biology (edit. by Cori, C. F., Foglia, V. G., Leloir, L. F., and Ochoa, S.) (Elsevier, 1963).

  5. 5

    Kenner, Th., and Waldhäusl, W., Zschr. Kreislauffschg., 54, 1143 (1965).

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  1. Institut für Allgemeine und Experimentelle Pathologie, Vienna, 9

    •  & W. WALDHÄUSL
  2. I. Medizinische Klinik, Vienna, 9

    •  & W. WALDHÄUSL


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