Abstract
Genetic experiments show that a group of genes may be switched off by the product of a regulator gene, called a repressor. An isolated repressor is shown here to bind specifically and with high affinity to DNA, strongly suggesting that, in vivo, repressors block the transcription from DNA to RNA by binding directly to the DNA.
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PTASHNE, M. Specific Binding of the λ Phage Repressor to λ DNA. Nature 214, 232–234 (1967). https://doi.org/10.1038/214232a0
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DOI: https://doi.org/10.1038/214232a0
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