Letter | Published:

Reduction in Radiation Lethality by Mixtures of Chemical Protectors

Naturevolume 214pages207208 (1967) | Download Citation



FOR more than 10 years, mixtures of chemical protectors have been used in order to increase the protection against radiation damage1. If different radioprotectors act via different mechanisms, one might hope that a simultaneous administration of several well chosen protectors would increase the protection. Thus, it seems reasonable to give simultaneously an SH protector with a substance causing anoxia2. It is also possible to add to a good chemical protector one or more compounds which decrease its toxicity3. Data are reported in this paper on short and long term survival of mice treated with different mixtures of chemical protectors before exposure to X-radiation.

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    Maisin, J. R., Rev. Franç. Et. Clin. Biol., 6, 378 (1961).

  2. 2

    Bacq, Z. M., Chemical Protection against Ionizing Radiation (Charles Thomas, Springfield, 1965).

  3. 3

    Maisin, J. R., Nature, 204, 196 (1964).

  4. 4

    Zins, G. R., Raymund, A. B., and Seidel, D. M., University of Chicago, U.S.A.F. Radiation Laboratory, Quarterly Report, 32, 14 (1959).

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    Bacq, Z. M., and Alexander, P., Nature, 203, 162 (1964).

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    Hugon, J., Maisin, J. R., and Borgers, M., C.R. Soc. Biol., 158, 201 (1964).

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    Hugon, J., Maisin, J. R., and Borgers, M., Experientia, 22, 235 (1966).

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    Maisin, J. R., Leonard, A., and Hugon, J., J. Nat. Cancer Inst., 35, 103 (1965).

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    Maisin, J. R., and Lambiet, M., Nature (in the press).

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  1. Department of Radiobiology, Centre d'Etude de I'Energie Nucléaire, Mol, Belgium

    • J. R. MAISIN
    •  & G. MATTELIN


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