Letter | Published:

Increased Tolerance to Posthaemorrhagic Shock in Dogs treated with Reserpine

Naturevolume 214pages202203 (1967) | Download Citation

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Abstract

THE mechanism governing the development and consequences of posthaemorrhagic circulatory collapse has been tentatively related to the activation of the sympathetico-adrenal system. During an early reversible stage after haemorrhage, this activation leads to compensatory readjustments; in a later irreversible stage the persisting sympathetico-adrenal activity brings about vascular and tissue lesions, especially at sites exposed to prolonged vasoconstriction. At this stage the situation cannot be remedied by restoring the blood volume.

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Affiliations

  1. Istituto di Farmacologia Medica, Universitá di Roma, Rome, Italy

    • L. ANGELUCCI
    •  & MIRELLA BALDIERI
  2. Centro Studi e Ricerche di Medicina Militare, Rome, Italy

    • M. BUONERBA

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https://doi.org/10.1038/214202a0

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