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New Peripheral Antagonists of 5-Hydroxytryptamine

Naturevolume 214pages200201 (1967) | Download Citation

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Abstract

PHARMACOLOGICAL screening of a series of guanidines1, formally related to the quaternary ammonium anthelmintic compound bephenium and its congeners2, revealed that B.W. 712C60 [(I), R1 = R2 = phenyl; A = (CH2)2] although devoid of such anthelmintic activity antagonized 5-hydroxytryptamine (5HT).

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References

  1. 1

    Copp, F. C., and Hodson, H. F., Brit. Pat., 1,031, 165.

  2. 2

    Copp, F. C., Standen, O. D., Scarnell, J., Rawes, D. A., and Burrows, R. B., Nature, 181, 183 (1958).

  3. 3

    Hodson, H. F., Belgian Pat., 666, 420.

  4. 4

    Gaddum, J. H., and Hameed, K. A., Brit. J. Pharmacol., 9, 240 (1954).

  5. 5

    Beretta, C., Ferrini, R., and Glässer, A. H., Nature, 207, 421 (1965).

  6. 6

    Konzett, H., and Rössler, R., Arch. Path. Pharmak., 195, 71 (1940).

  7. 7

    Tedeschi, D. H., Tedeschi, R. E., and Fellows, E. J., J. Pharm. Exp. Ther., 126, 223 (1959).

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Affiliations

  1. The Wellcome Research Laboratories, Beckenham, Kent

    • F. C. COPP
    • , A. F. GREEN
    • , H. F. HODSON
    • , A. W. RANDALL
    •  & M. F. SIM

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https://doi.org/10.1038/214200a0

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