Letter | Published:

Possible Mode of Action of Acetylcholine

Naturevolume 214pages199200 (1967) | Download Citation

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Abstract

ACETYLCHOLINE is accepted as a transmitter at certain locations, but in spite of some theories1,2 the basis of its action remains unclear. Proposed correlations between permeability changes of sensitive membranes and surface tension have also remained controversial3–5, and the present investigation of acetylcholine is concerned with this relationship. The choline-glycerophosphatides are twice as concentrated in grey as in white matter6, and we therefore used lecithin and its components as the test substrates.

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References

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    Barnes, T. C., and Beutner, R., Med. Physics (edit. by Glasser, Otto), 2, 81 (The Yearbook Publ., Inc., 1950).

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    Hokin, M. R., and Hokin, L. E., J. Biol. Chem., 209, 549 (1954).

  3. 3

    Shanes, A. M., Pharmacol. Rev., 10, No. 1, 87 (March, 1958).

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    Shanes, A. M., and Gershfeld, N. L., J. Gen. Phys., 44, 345 (1960).

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    Skou, J. C., Acta. Pharm. tox. Kbh., 10, 305 (1954).

  6. 6

    O'Brien, J. S., Science, 147, 1099 (1965).

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    Stevens, J. D., Dis. Nervous System, 27, No. 5, 326 (1966).

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    • JOHN D. STEVENS

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DOI

https://doi.org/10.1038/214199a0

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