Letter | Published:

Effects of “Haematoporphyrin” on Adhesiveness and Aggregation of Rabbit Platelets

Naturevolume 214pages186187 (1967) | Download Citation



IN the course of investigations on the modification of tumour radiosensitivity by porphyrins1–4, we have found that haematoporphyrin (HP) decreases platelet adhesiveness to glass and platelet aggregation induced by adenosinc diphosphate (ADP). Recent reports have described micro-agglutination of erythrocytes5 and destructive changes in platelets6 produced by HP in the presence of light of wavelengths corresponding to absorption maxima of HP. The present observations, however, were made in the absence of such radiation.

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    Schwartz, S., Absolon, K., and Vermund, H., Univ. Minn. Med. Bull., 27, 7 (1955).

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    Schwartz, S., in Les Maladies du Metabolisme des Porphyrins, 2e Colloque Internation de Biologie de Saclay (edit. by Fallot, P.), 251 (Presses. Universitaires de France, 1960).

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    Cohen, L., and Schwartz, S., Cancer Res., 26, 1769 (1966).

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    Modell, J., and Schwartz, S., Proc. Soc. Exp. Biol. and Med., 116, 395 (1964).

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    Castellani, A., Pace, G. P., and Concioli, M., J. Path. Bact., 86, 99 (1963).

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    Salzman, E. W., Chambers, D. A., and Neri, L. L., Nature, 210, 167 (1966).

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  1. Department of Medicine, University of Minnesota, Minneapolis, Minnesota



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