Letter | Published:

Bone Marrow and Lymphoid Cell Injection of the Pig Foetus resulting in Transplantation Tolerance or Immunity, and Immunoglobulin Production

Naturevolume 214pages179181 (1967) | Download Citation



IT is known that the pig is capable at birth of immune responses to some antigens (phage1,2; animal viruses3–5; toxoids6; and homografts7,8). The finding that thymectomy in neonatal pigs is without effect on homograft rejection8 also suggests that the pig, unlike many laboratory rodents9,10 acquires the faculty of graft rejection before birth. Information on immune responses of pig foetuses to injected antigens has not been found in the literature. This communication outlines such research.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Kim, Y. B., Bradley, S. G., and Watson, D. W., Fed. Proc., 23, 346 (1964).

  2. 2

    Kim, Y. B., Bradley, S. G., and Watson, D. W., J. Immunol., 97, 52 (1966).

  3. 3

    Weide, K. D., Sanger, V. L., and Lagrace, A., J. Amer. Vet. Med. Assoc., 141, 464 (1962).

  4. 4

    Aiken, J. M., and Blore, I. C., Amer. J. Vet. Res., 25, 1134 (1964).

  5. 5

    Kelly, D. F., J. Comp. Path., 74, 381 (1964).

  6. 6

    Segre, D., and Kaeberle, M. L., J. Immunol., 89, 790 (1962).

  7. 7

    Sterzl, J., Kostka, J., Mandel, L., Riha, I., and Holub, M., in Mechanism of Antibody Formation, 130 (Publ. House Czechoslov. Acad. Sci., 1960).

  8. 8

    Pestana, C., Hallenbeck, G. A., and Shorter, R. G., J. Surg. Res., 5, 306 (1965).

  9. 9

    Miller, J. F. A. P., Brit. Med. Bull., 22, 21 (1966).

  10. 10

    Good, R. A., and Papermaster, B. W., Adv. in Immunol., 4, 1 (1964).

  11. 11

    Binns, R. M., and Hall, J. G., Brit. J. Exp. Path., 47, 275 (1966).

  12. 12

    Silverstein, A. M., Thorbecke, G. J., Kraner, K. L., and Lukes, R. J., J. Immunol., 91, 384 (1963).

  13. 13

    Billingham, R. E., and Brent, L., Phil. Trans. Roy. Soc., B, 242, 439 (1959).

Download references

Author information


  1. Department of Experimental Pathology, A.R.C. Institute of Animal Physiology, Babraham, Cambridge

    • R. M. BINNS


  1. Search for R. M. BINNS in:

About this article

Publication history


Issue Date



Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.