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Protective Effect of Anti-lymphocytic Serum on Murine Lymphocytic Choriomeningitis

Naturevolume 214pages178179 (1967) | Download Citation



LYMPHOCYTIC choriomeningitis (LCM) virus inoculated intracerebrally into mice produces a disease that is usually fatal. Such infections are, however, rarely fatal in mice that have been X-irradiated1,2 or treated with radiomimetic drugs3, although they carry the virus in high concentration indefinitely. These and other observations suggested that the lethal disease results from a hypersensitive reaction against the virus or against some product of the virus4,5, and certain evidence seems to implicate cells of the central nervous system in this reaction6. Congenitally infected mice do not develop acute illness, although they maintain high levels of viraemia throughout their lives7. When such mice are inoculated with adequate numbers of histo-compatible lymphocytes from immunized animals no sign of illness develops, but the level of viraemia is greatly reduced8. This observation appears to conflict with the hypothesis that severe lymphocytic choriomeningitis is a manifestation of a hypersensitivity reaction.

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  1. National Institute for Medical Research, Mill Hill, London

    • A. W. GLEDHILL


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