Letter | Published:

Identity of Feline Ataxia Virus with Feline Panleucopenia Virus

Naturevolume 214pages175177 (1967) | Download Citation



Kilham and Margolis1 investigated the cerebellar hypoplasia associated with feline ataxia (FA), a spontaneously occurring disease of kittens previously believed to be of genetic origin2. They demonstrated that the condition could be reproduced by passage of affected cerebellum emulsions in neonatal kittens or ferrets, and found that the transmissible factor was a filterable agent resistant to treatment with heat and ether; this they designated feline ataxia virus (FAV). The properties of FAV led them to compare the virus with the serologically distinct Kilham rat virus (RV)3 and hamster osteolytic virus H–I4, of which the former can induce similar cerebellar hypoplasia in cats5, rats6, and hamsters7. From a different line of research, Johnson and Cruickshank8 concluded that the properties of feline panleucopenia (FP) virus were similar to those of RV and H–I. Subsequent correspondence between the two groups led to the present report.

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  1. Department of Veterinary Medicine, University of Bristol

    • R. H. JOHNSON
  2. Department of Pathology, Hanover, New Hampshire

  3. Department of Microbiology, Dartmouth Medical School, Hanover, New Hampshire



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