Letter | Published:

Identity of Feline Ataxia Virus with Feline Panleucopenia Virus

Naturevolume 214pages175177 (1967) | Download Citation

Subjects

Abstract

Kilham and Margolis1 investigated the cerebellar hypoplasia associated with feline ataxia (FA), a spontaneously occurring disease of kittens previously believed to be of genetic origin2. They demonstrated that the condition could be reproduced by passage of affected cerebellum emulsions in neonatal kittens or ferrets, and found that the transmissible factor was a filterable agent resistant to treatment with heat and ether; this they designated feline ataxia virus (FAV). The properties of FAV led them to compare the virus with the serologically distinct Kilham rat virus (RV)3 and hamster osteolytic virus H–I4, of which the former can induce similar cerebellar hypoplasia in cats5, rats6, and hamsters7. From a different line of research, Johnson and Cruickshank8 concluded that the properties of feline panleucopenia (FP) virus were similar to those of RV and H–I. Subsequent correspondence between the two groups led to the present report.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Kilham, L., and Margolis, G., Amer. J. Path., 48, 6, 991 (1966).

  2. 2

    Innes, J. R. M., and Saunders, L. Z., Comparative Neuropathology, 307 (Academic Press, New York and London, 1962).

  3. 3

    Kilham, L., and Olivier, L. J., Virology, 7, 428 (1959).

  4. 4

    Toolan, H. W., Bull. N.Y. Acad. Med., 37, 305 (1961).

  5. 5

    Kilham, L., and Margolis, G., Science, 148, 244 (1965).

  6. 6

    Kilham, L., and Margolis, G., Amer. J. Path., 49, 457 (1966).

  7. 7

    Kilham, L., and Margolis, G., Science, 143, 1047 (1964).

  8. 8

    Johnson, R. H., and Cruickshank, G., Nature, 212, 622 (1966).

  9. 9

    Johnson, R. H., Res. Vet. Sci., 6, 472 (1965).

  10. 10

    Johnson, R. H., thesis, Univ. Bristol (1966).

  11. 11

    Johnson, R. H., Res. Vet. Sci., 6, 466 (1965).

  12. 12

    Mayor, H. D., and Melnick, J. L., Nature, 210, 331 (1966).

  13. 13

    Hindle, E., and Findlay, G. M., J. Comp. Path., 45, 11 (1932).

  14. 14

    Hammon, W. G., and Enders, J. F., J. Exp. Med., 69, 327 (1939).

  15. 15

    Margolis, G., and Kilham, L., NINDB Monograph, 2, 361 (1966).

Download references

Author information

Affiliations

  1. Department of Veterinary Medicine, University of Bristol

    • R. H. JOHNSON
  2. Department of Pathology, Hanover, New Hampshire

    • GEORGE MARGOLIS
  3. Department of Microbiology, Dartmouth Medical School, Hanover, New Hampshire

    • LAWRENCE KILHAM

Authors

  1. Search for R. H. JOHNSON in:

  2. Search for GEORGE MARGOLIS in:

  3. Search for LAWRENCE KILHAM in:

About this article

Publication history

Issue Date

DOI

https://doi.org/10.1038/214175a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.