Article | Published:

Teratogenic Activity of Nitrous Oxide

Naturevolume 214pages146148 (1967) | Download Citation

Subjects

Abstract

Exposure of pregnant rats to an atmosphere containing nitrous oxide resulted in foetuses with abnormalities of vertebrae and ribs, and in death and resorption of foetuses. The lethal effects seemed to be selective, for surviving foetuses showed a smaller male/female sex ratio than did the controls.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Fink, B. R., and Kenny, G. E., Fed. Proc., 25, 56 (1966).

  2. 2

    Rector, G. H. M., and Eastwood, D. W., Anesthesiology, 25, 109 (1964).

  3. 3

    Blandau, R. J., Boling, J. L., and Young, W. C., Anat. Rec., 79, 453 (1941).

  4. 4

    Walker, D. G., and Wirtschafter, Z. T., The Genesis of the Rat Skeleton, 6 (Charles C. Thomas, Springfield, Illinois, 1957).

  5. 5

    Tricomi, V., Serr, D., and Solish, G., Amer. J. Obstet. Gynec., 79, 504 (1960).

  6. 6

    Hurst, E. W., in The Evaluation of Drug Toxicity (edit. by Walpole, A. L., and Spinks, A.), 12 (Little, Brown and Co., Boston, 1958).

  7. 7

    Nicol, T., Vernon-Roberts, B., and Quantock, D. C., Nature, 208, 1098 (1965).

  8. 8

    Hahn, E. W., and Hays, R. L., J. Reprod. Fertil., 6, 409 (1963).

  9. 9

    Russell, L. B., J. Exp. Zool., 114, 545 (1950).

  10. 10

    Job, T. T., Leibold, G. J., and Fitzmaurice, H. A., Amer. J. Anat., 56, 97 (1935).

  11. 11

    Rugh, R., and Wohlfromm, M., Nature, 210, 969 (1966).

  12. 12

    Fox, M. H., and Goss, C. M., Anat. Rec., 124, 189 (1956).

  13. 13

    Fisher, R. A., in Statistical Methods for Research Workers, twelfth edition, Section 21, 95 (Oliver and Boyd, London, 1954).

  14. 14

    Waddington, C. H., and Carter, T. C., J. Exp. Embryol. Morph., 1, 167 (1953).

  15. 15

    Haring, O. M., Circulation Res., 8, 1218 (1960).

  16. 16

    Ingalls, T. H., Curley, F. J., and Prindle, R. A., New Engl. J. Med., 274, 758 (1952).

  17. 17

    Ebert, M., and Hornsey, S., Nature, 181, 613 (1958).

  18. 18

    Green, C., and Eastwood, D. W., Anesthesiology, 24, 341 (1963).

Download references

Author information

Affiliations

  1. Departments of Anesthesiology, Pediatrics and Biological Structure, University of Washington School of Medicine, Seattle, Washington

    • B. R. FINK
    • , T. H. SHEPARD
    •  & R. J. BLANDAU

Authors

  1. Search for B. R. FINK in:

  2. Search for T. H. SHEPARD in:

  3. Search for R. J. BLANDAU in:

About this article

Publication history

Issue Date

DOI

https://doi.org/10.1038/214146a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.