Abstract
WE have described the in vitro alteration of the blood group I receptor of the red cell by mycoplasma, and stated that the effect was greater on group A cells than on group O cells1. We also noted that Clostridium filtrates which had been reported by other workers to destroy the specific I determinant were more active against group A than against group O cells2. For these reasons we used group A1I red cells in our final test system which employed the gamma macroglobulin fraction from a group A2 patient who was I negative as our agglutinating reagent. Feizi and Darrell have now reported their failure to find an effect of mycoplasma on the receptors for I. Unfortunately, they used group OI cells instead of group AI cells in their test system3.
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Schmidt, P. J., Barile, M. F., and McGinniss, M. H., Nature, 205, 371 (1965).
Marcus, D. M., Kabat, E. A., and Rosenfleld, R. E., J. Exp. Med., 118, 175 (1963).
Feizi, T., and Darrell, J. H., Nature, 211, 1159 (1966).
Race, R. R., and Sanger, R., Blood Groups in Man, fourth ed., 334 (Blackwell, Oxford, 1962).
Tippett, P., Noades, J., Sanger, R., Race, R., Sausais, L., Holman, C. A., and Buttimer, R. J., Vox Sang., 5, 107 (1960).
Tegoli, J., Harris, J. P., Issitt, P. D., and Sanders, C. W., Vox Sang. (in the press).
Yokoyama, M., Nature, 206, 411 (1965).
Yokoyama, M., and Plocinik, B. A., Z. Immunitätsforsch., 129, 137 (1965).
Feizi, T., and Hardisty, R. M., Nature, 210, 1066 (1966).
Rosenfield, R. E., Schroeder, R., Ballard, R., van der Hart, M., Moes, M., and van Loghem, J. J., Vox Sang., 9, 415 (1964).
Gold, E. R., Vox Sang., 9, 153 (1964).
Ducos, J., Ruffie, J., Colombies, P., Marty, P., and Ohayon, E., Nature, 208, 1329 (1965).
Salmon, C., Salmon, D., Mioueri, C., and Berthier, J., Nouv. Rev. Franc. d'Hémat., 6, 563 (1966).
Jenkins, W. J., Marsh, W. L., and Gold, E. R., Nature, 205, 813 (1965).
Tonder, O., and Harboe, M., Immunology, 11, 361 (1966).
Yokoyama, M., Stegmaier, A., Gilbert, F. I., Fukunaga, F. M., and Paik, Y. K., Hawaii Med. J., 25, 106 (1965).
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SCHMIDT, P., MCGINNISS, M. Cell Surfaces, Blood Groups and Microorganisms. Nature 214, 1363 (1967). https://doi.org/10.1038/2141363a0
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DOI: https://doi.org/10.1038/2141363a0
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