NINE species of coccidia are known to parasitize the domestic fowl. During the past 25 years a succession of drugs has made it possible to control coccidiosis to an increasing degree, but until recently no drug was known which would effectively suppress all species. Wide-spectrum prophylaxis has been most successfully accomplished by the use of mixtures such as amprolium + ethopabate + sulphaquinoxaline. We now report the discovery that methyl 7-benzyloxy-6-n-butyl-4-oxo-1,4-dihydroquinoline-3-carboxylate (I; R1 = CH3, R2 = n C4H9, R3 = C6H5·CH2·O) has prophylactic activity against all six important species of coccidia and is more than ten times as active as any available alternative coccidiostat.
Spencer, C. F., Engle, A., Chia-Nien Yu Finch, R. C., Watson, E. J., Ebetino, F. F., and Johnson, C. A., J. Med. Chem., 9, 934 (1966).
Stock, B. L., Stevenson, G. T., and Hymas, T. A., Poultry Science, 45, 1127 (1966).
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BOWIE, R., CAIRNS, J., GRANT, M. et al. A New Wide-spectrum Coccidiostat. Nature 214, 1349 (1967). https://doi.org/10.1038/2141349a0