A New Wide-spectrum Coccidiostat

Abstract

NINE species of coccidia are known to parasitize the domestic fowl. During the past 25 years a succession of drugs has made it possible to control coccidiosis to an increasing degree, but until recently no drug was known which would effectively suppress all species. Wide-spectrum prophylaxis has been most successfully accomplished by the use of mixtures such as amprolium + ethopabate + sulphaquinoxaline. We now report the discovery that methyl 7-benzyloxy-6-n-butyl-4-oxo-1,4-dihydroquinoline-3-carboxylate (I; R1 = CH3, R2 = n C4H9, R3 = C6H5·CH2·O) has prophylactic activity against all six important species of coccidia and is more than ten times as active as any available alternative coccidiostat.

References

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BOWIE, R., CAIRNS, J., GRANT, M. et al. A New Wide-spectrum Coccidiostat. Nature 214, 1349 (1967). https://doi.org/10.1038/2141349a0

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