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Urinary Excretion of Isethionic Acid in Man

Abstract

THE main end products of the metabolism of sulphur amino-acids in mammals are inorganic sulphate and taurine1,2. In mammalian liver, taurine participates in the formation of conjugated bile acids3. Substantial amounts of taurine are, however, present in many extra-hepatic tissues, notably heart, muscle, brain, skin, leucocytes and platelets4–7. The biological function, if any, of taurine in these tissues is unknown.

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References

  1. Young, L., and Maw, G. A., The Metabolism of Sulphur Compounds, 33 (Methuen and Co., Ltd., London, 1958).

    Google Scholar 

  2. Kun, E., in Metabolic Pathways (edit. by Greenberg, D. M.), 2, 237 (Academic Press, New York and London, 1961).

    Book  Google Scholar 

  3. Bremer, J., and Gloor, U., Acta Chem. Scand., 9, 689 (1955).

    Article  CAS  Google Scholar 

  4. Awapara, J., J. Biol. Chem., 218, 571 (1956).

    CAS  PubMed  Google Scholar 

  5. Garvin, J. E., Arch. Biochem. Biophys., 91, 219 (1960).

    Article  CAS  Google Scholar 

  6. Vinh An, Huynh, and Fromageot, P., Bull. Soc. Chim. Biol., 42, 221 (1960).

    Google Scholar 

  7. Soupart, P., in Amino Acid Pools (edit. by Holden, J. T.), 220 (Elsevier Publishing Co., Amsterdam, London and New York, 1962).

    Google Scholar 

  8. Koechlin, B. A., Proc. U. S. Nat. Acad. Sci., 40, 60 (1954).

    Article  ADS  CAS  Google Scholar 

  9. Koechlin, B. A., J. Biophys. Biochem. Cytol., 1, 511 (1955).

    Article  CAS  Google Scholar 

  10. Deffner, G. G. J., and Hafter, R. E., Biochim. Biophys. Acta, 42, 200 (1960).

    Article  CAS  Google Scholar 

  11. Braun, R., and Fromageot, P., Biochim. Biophys. Acta, 62, 548 (1962).

    Article  CAS  Google Scholar 

  12. Cotty, V. F., Henry, S. M., and Hilchey, J. D., Contr. Boyce Thompson Inst., 19, 379 (1958).

    CAS  Google Scholar 

  13. Schram, E., Arch. Intern. Physiol. Biochem., 68, 698 (1960).

    Google Scholar 

  14. Welty, J. D., Read, W. O., and Shaw, jun., E. H., J. Biol. Chem., 237, 1160 (1962).

    CAS  PubMed  Google Scholar 

  15. Read, W. 0., and Welty, J. D., J. Biol. Chem., 237, 1521 (1962).

    CAS  PubMed  Google Scholar 

  16. Welty, jun., J. D., thesis, Univ. South Dakota (1963).

  17. Peck, jun., E. J., and Awapara, J., Fed. Proc., 25, 642 (1966).

    Google Scholar 

  18. Jacobsen, J. G., and Smith, jun., L. H., Nature, 200, 575 (1963).

    Article  ADS  CAS  Google Scholar 

  19. Jacobsen, J. G., Thomas, L. L., and Smith, jun., L. H., Biochim. Biophys. Acta, 85, 103 (1964).

    CAS  PubMed  Google Scholar 

  20. Kliman, B., and Peterson, R. E., J. Biol. Chem., 235, 1639 (1960).

    CAS  PubMed  Google Scholar 

  21. Gibbs, W., Amer. J. Sci., second ser., 25, 18 (1858).

    Google Scholar 

  22. Peterson, D. W., Lilyblade, A. L., and Lyon, J., Proc. Soc. Exp. Biol. and Med., 113, 798 (1963).

    Article  CAS  Google Scholar 

  23. Tyler, F. H., in The Metabolic Basis of Inherited Disease (edit. by Stanbury, J. B., Wyngaarden, J. B., and Frederickson, D. S.), 939 (McGraw-Hill Book Co., New York and London, 1966).

    Google Scholar 

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JACOBSEN, J., COLLINS, L. & SMITH, L. Urinary Excretion of Isethionic Acid in Man. Nature 214, 1247–1248 (1967). https://doi.org/10.1038/2141247a0

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